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Articles, Cellular/Molecular

Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus

Niels Haan, Timothy Goodman, Alaleh Najdi-Samiei, Christina M. Stratford, Ritva Rice, Elie El Agha, Saverio Bellusci and Mohammad K. Hajihosseini
Journal of Neuroscience 3 April 2013, 33 (14) 6170-6180; https://doi.org/10.1523/JNEUROSCI.2437-12.2013
Niels Haan
1School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom,
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Timothy Goodman
1School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom,
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Alaleh Najdi-Samiei
1School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom,
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Christina M. Stratford
1School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom,
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Ritva Rice
2Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland,
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Elie El Agha
3Excellence Cluster Cardio-Pulmonary System (ECCPS), University Justus Liebig, 35392 Giessen, Germany,
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Saverio Bellusci
3Excellence Cluster Cardio-Pulmonary System (ECCPS), University Justus Liebig, 35392 Giessen, Germany,
4Saban Research Institute of Children's Hospital Los Angeles, University of California Los Angeles, Los Angeles, California 90027
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Mohammad K. Hajihosseini
1School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom,
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Abstract

Increasing evidence suggests that neurogenesis occurs in the postnatal and adult mammalian hypothalamus. However, the identity and location of the putative progenitor cells is under much debate, and little is known about the dynamics of neurogenesis in unchallenged brain. Previously, we postulated that Fibroblast growth factor 10-expressing (Fgf10+) tanycytes constitute a population of progenitor cells in the mouse hypothalamus. Here, we show that Fgf10+ tanycytes express markers of neural stem/progenitor cells, divide late into postnatal life, and can generate both neurons and astrocytes in vivo. Stage-specific lineage-tracing of Fgf10+ tanycytes using Fgf10-creERT2 mice, reveals robust neurogenesis at postnatal day 28 (P28), lasting as late as P60. Furthermore, we present evidence for amplification of Fgf10-lineage traced neural cells within the hypothalamic parenchyma itself. The neuronal descendants of Fgf10+ tanycytes predominantly populate the arcuate nucleus, a subset of which express the orexigenic neuronal marker, Neuropeptide-Y, and respond to fasting and leptin-induced signaling. These studies provide direct evidence in support of hypothalamic neurogenesis during late postnatal and adult life, and identify Fgf10+ tanycytes as a source of parenchymal neurons with putative roles in appetite and energy balance.

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The Journal of Neuroscience: 33 (14)
Journal of Neuroscience
Vol. 33, Issue 14
3 Apr 2013
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Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus
Niels Haan, Timothy Goodman, Alaleh Najdi-Samiei, Christina M. Stratford, Ritva Rice, Elie El Agha, Saverio Bellusci, Mohammad K. Hajihosseini
Journal of Neuroscience 3 April 2013, 33 (14) 6170-6180; DOI: 10.1523/JNEUROSCI.2437-12.2013

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Fgf10-Expressing Tanycytes Add New Neurons to the Appetite/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus
Niels Haan, Timothy Goodman, Alaleh Najdi-Samiei, Christina M. Stratford, Ritva Rice, Elie El Agha, Saverio Bellusci, Mohammad K. Hajihosseini
Journal of Neuroscience 3 April 2013, 33 (14) 6170-6180; DOI: 10.1523/JNEUROSCI.2437-12.2013
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