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Brief Communications

MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

Arie Reijerkerk, M. Alejandro Lopez-Ramirez, Bert van het Hof, Joost A.R. Drexhage, Wouter W. Kamphuis, Gijs Kooij, Joost B. Vos, Tineke C.T.M. van der Pouw Kraan, Anton J. van Zonneveld, Anton J. Horrevoets, Alexandre Prat, Ignacio A. Romero and Helga E. de Vries
Journal of Neuroscience 17 April 2013, 33 (16) 6857-6863; https://doi.org/10.1523/JNEUROSCI.3965-12.2013
Arie Reijerkerk
1Blood–Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
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M. Alejandro Lopez-Ramirez
2Department of Life, Health & Chemical Sciences, The Open University, Milton Keynes MK7 6AA, United Kingdom,
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Bert van het Hof
1Blood–Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
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Joost A.R. Drexhage
1Blood–Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
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Wouter W. Kamphuis
1Blood–Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
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Gijs Kooij
1Blood–Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
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Joost B. Vos
3Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
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Tineke C.T.M. van der Pouw Kraan
3Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
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Anton J. van Zonneveld
4Department of Nephrology and Einthoven Laboratory for Experimental Vascular Research, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands, and
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Anton J. Horrevoets
3Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
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Alexandre Prat
5Neuroimmunology Research Laboratory, Centre of Excellence in Neuromics, CHUM-Notre-Dame Hospital, Faculty of Medicine, Université de Montréal, Montréal, Quebec H2L 4M1, Canada
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Ignacio A. Romero
2Department of Life, Health & Chemical Sciences, The Open University, Milton Keynes MK7 6AA, United Kingdom,
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Helga E. de Vries
1Blood–Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3965-12.2013
PubMed 
23595744
Published By 
Society for Neuroscience
History 
  • Received August 20, 2012
  • Revision received February 18, 2013
  • Accepted February 27, 2013
  • First published April 17, 2013.
  • Version of record published April 17, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/336857-07$15.00/0

Author Information

  1. Arie Reijerkerk1,*,
  2. M. Alejandro Lopez-Ramirez2,*,
  3. Bert van het Hof1,
  4. Joost A.R. Drexhage1,
  5. Wouter W. Kamphuis1,
  6. Gijs Kooij1,
  7. Joost B. Vos3,
  8. Tineke C.T.M. van der Pouw Kraan3,
  9. Anton J. van Zonneveld4,
  10. Anton J. Horrevoets3,
  11. Alexandre Prat5,
  12. Ignacio A. Romero2,†, and
  13. Helga E. de Vries1,†
  1. 1Blood–Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
  2. 2Department of Life, Health & Chemical Sciences, The Open University, Milton Keynes MK7 6AA, United Kingdom,
  3. 3Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands,
  4. 4Department of Nephrology and Einthoven Laboratory for Experimental Vascular Research, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands, and
  5. 5Neuroimmunology Research Laboratory, Centre of Excellence in Neuromics, CHUM-Notre-Dame Hospital, Faculty of Medicine, Université de Montréal, Montréal, Quebec H2L 4M1, Canada
View Full Text

Author contributions

  1. Author contributions: A.R., I.A.R., and H.E.d.V. designed research; A.R., M.A.L.-R., B.v.h.H., J.A.R.D., W.K., G.K., and J.B.V. performed research; A.P. contributed unpublished reagents/analytic tools; A.R., M.A.L.-R., J.B.V., T.C.T.M.v.d.P.K., A.J.v.Z., and A.J.H. analyzed data; A.R. and H.E.d.V. wrote the paper.

  2. ↵*A.R. and M.A.L.-R. contributed equally to this work.

  3. ↵†I.A.R. and H.E.d.V. contributed equally to this work.

Disclosures

    • Received August 20, 2012.
    • Revision received February 18, 2013.
    • Accepted February 27, 2013.
  • This work was supported by grants from the Netherlands Genomics Initiative (A.R., J.A.R.D.), the MS Research Foundation (A.R. and H.E.d.V., Grant 08-642), ZonMw [J.B.V.; DPTE (Dutch Program Tissue Engineering) Grant LGT.6918], and Multiple Sclerosis Society of Great Britain and Northern Ireland (I.A.R.). The funders had no role in study design, data collection, and analysis; decision to publish; or preparation of the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Helga E. de Vries, Blood–Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands, he.devries{at}vumc.nl; or Ignacio A. Romero, Department of Life, Health & Chemical Sciences, The Open University, Milton Keynes MK7 6AA, United Kingdom. i.romero{at}open.ac.uk

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Total63935901384
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The Journal of Neuroscience: 33 (16)
Journal of Neuroscience
Vol. 33, Issue 16
17 Apr 2013
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MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis
Arie Reijerkerk, M. Alejandro Lopez-Ramirez, Bert van het Hof, Joost A.R. Drexhage, Wouter W. Kamphuis, Gijs Kooij, Joost B. Vos, Tineke C.T.M. van der Pouw Kraan, Anton J. van Zonneveld, Anton J. Horrevoets, Alexandre Prat, Ignacio A. Romero, Helga E. de Vries
Journal of Neuroscience 17 April 2013, 33 (16) 6857-6863; DOI: 10.1523/JNEUROSCI.3965-12.2013

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MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis
Arie Reijerkerk, M. Alejandro Lopez-Ramirez, Bert van het Hof, Joost A.R. Drexhage, Wouter W. Kamphuis, Gijs Kooij, Joost B. Vos, Tineke C.T.M. van der Pouw Kraan, Anton J. van Zonneveld, Anton J. Horrevoets, Alexandre Prat, Ignacio A. Romero, Helga E. de Vries
Journal of Neuroscience 17 April 2013, 33 (16) 6857-6863; DOI: 10.1523/JNEUROSCI.3965-12.2013
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