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Cover legend: 3D reconstruction of abnormal hypertrophic astrocytes with long, thick processes in the hippocampus of a mouse model of Alexander disease (GFAPTg). Astrocytes are immunostained for glial fibrillary acidic protein (GFAP) with Nissl counterstain for nuclei. For more information, see the article by Sosunov et al. (pages 7439–7450).