Selective Silencing of Individual Dendritic Branches by an mGlu2-Activated Potassium Conductance in Dentate Gyrus Granule Cells

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¹ Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary,
²Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland,
³Department of Molecular and Cell Biology, Aptuit Verona, 37135 Verona, Italy, and
⁴ Department of Pharmacology, Innsbruck Medical University, A-6020 Innsbruck, Austria

Author contributions: J.B., J. Ster, F.F., U.G., and J. Szabadics designed research; J.B., J. Ster, S.V.-W., T.A., M.N., F.F., and J. Szabadics performed research; C.C. and M.C. contributed unpublished reagents/analytic tools; J.B., J. Ster, F.F., and J. Szabadics analyzed data; F.F., U.G., and J. Szabadics wrote the paper.
↵*J.B. and J. Ster contributed equally to this work.

This work was funded by the Wellcome Trust (International Senior Research Fellowship #087497 to J.S.), the Hungarian Academy of Sciences (Lendület Iinitiative #LP-2009–009 to J.S.), Gedeon Richter (to J.S.), and the Swiss National Science Foundation (to U.G.). We thank the Nikon Microscopy Center at IEM, Nikon Austria GmbH, Auro-Science Consulting Ltd, and László Barna for kindly providing microscopy support, Norbert Hájos, Roland Krueppel, Andrea Lörincz, and Zoltán Nusser for valuable comments on an earlier version of the manuscript, Szabolcs Káli for his help with the Neuron 7.2 simulation environment, Dóra Hegedús, Andrea Juszel, D. Göckeritz-Dujmovic, S. Giger, and H Kasper for technical assistance, and Shigetada Nakanishi for permission to use the mGlu2^−/− mice.
Correspondence should be addressed to one of the following: Urs Gerber, Brain Research Institute, Winterthurerstrasse 190, University of Zurich, CH-8057 Zurich, Switzerland, gerber{at}hifo.uzh.ch; or János Szabadics, Institute of Experimental Medicine, Szigony utca 43, Budapest 1083, Hungary, szabadics.janos{at}koki.mta.hu

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