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Articles, Neurobiology of Disease

Homeostatic Responses Fail to Correct Defective Amygdala Inhibitory Circuit Maturation in Fragile X Syndrome

Rebecca L. Vislay, Brandon S. Martin, Jose Luis Olmos-Serrano, Sebila Kratovac, David L. Nelson, Joshua G. Corbin and Molly M. Huntsman
Journal of Neuroscience 24 April 2013, 33 (17) 7548-7558; https://doi.org/10.1523/JNEUROSCI.2764-12.2013
Rebecca L. Vislay
1Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010,
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Brandon S. Martin
1Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010,
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Jose Luis Olmos-Serrano
1Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010,
2Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118,
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Sebila Kratovac
1Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010,
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David L. Nelson
3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, and
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Joshua G. Corbin
1Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010,
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Molly M. Huntsman
4Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2764-12.2013
PubMed 
23616559
Published By 
Society for Neuroscience
History 
  • Received June 9, 2012
  • Revision received March 14, 2013
  • Accepted March 15, 2013
  • First published April 24, 2013.
  • Version of record published April 24, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/337548-11$15.00/0

Author Information

  1. Rebecca L. Vislay1,
  2. Brandon S. Martin1,
  3. Jose Luis Olmos-Serrano1,2,
  4. Sebila Kratovac1,
  5. David L. Nelson3,
  6. Joshua G. Corbin1, and
  7. Molly M. Huntsman4
  1. 1Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010,
  2. 2Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118,
  3. 3Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, and
  4. 4Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045
View Full Text

Author contributions

  1. Author contributions: R.L.V., J.G.C., and M.M.H. designed research; R.L.V., B.S.M., J.L.O.-S., S.K., and D.L.N. performed research; R.L.V., J.G.C., and M.M.H. analyzed data; R.L.V., B.S.M., J.G.C., and M.M.H. wrote the paper.

Disclosures

    • Received June 9, 2012.
    • Revision received March 14, 2013.
    • Accepted March 15, 2013.
  • This work was supported by National Institutes of Health/National Institute of Neurological Disorders and Stroke Grant R01 NS053719 (M.M.H.), Autism Speaks (J.G.C. and M.M.H.), Neurodevelopmental Disorders Fund (J.G.C.), FRAXA Research Foundation (J.G.C. and M.M.H.), a National Institute of Child Health and Human Development T32 Training Grant (R.L.V.), and National Institutes of Health Grant HD024064 (D.L.N.). We acknowledge the members of the Huntsman and Corbin laboratories for useful discussions and Stefano Vicini and Vittorio Gallo for advice and critical reading of this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Dr. Molly M. Huntsman, Departments of Pharmaceutical Sciences and Pediatrics, University of Colorado/Anschutz Medical Campus, 12850 East Montview Boulevard, V20-3121, Aurora, CO 80045; Molly.Huntsman{at}UCDenver.edu; or Dr. Joshua G. Corbin, Center for Neuroscience Research, Children's National Medical Center, 111 Michigan Avenue NW, Room M7639, Washington, DC 20010; JCorbin{at}childrensnational.org

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Total 202550424146
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The Journal of Neuroscience: 33 (17)
Journal of Neuroscience
Vol. 33, Issue 17
24 Apr 2013
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Homeostatic Responses Fail to Correct Defective Amygdala Inhibitory Circuit Maturation in Fragile X Syndrome
Rebecca L. Vislay, Brandon S. Martin, Jose Luis Olmos-Serrano, Sebila Kratovac, David L. Nelson, Joshua G. Corbin, Molly M. Huntsman
Journal of Neuroscience 24 April 2013, 33 (17) 7548-7558; DOI: 10.1523/JNEUROSCI.2764-12.2013

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Homeostatic Responses Fail to Correct Defective Amygdala Inhibitory Circuit Maturation in Fragile X Syndrome
Rebecca L. Vislay, Brandon S. Martin, Jose Luis Olmos-Serrano, Sebila Kratovac, David L. Nelson, Joshua G. Corbin, Molly M. Huntsman
Journal of Neuroscience 24 April 2013, 33 (17) 7548-7558; DOI: 10.1523/JNEUROSCI.2764-12.2013
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