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Articles, Behavioral/Cognitive

Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors

Shahrdad Lotfipour, Janet S. Byun, Prescott Leach, Christie D. Fowler, Niall P. Murphy, Paul J. Kenny, Thomas J. Gould and Jim Boulter
Journal of Neuroscience 1 May 2013, 33 (18) 7728-7741; DOI: https://doi.org/10.1523/JNEUROSCI.4731-12.2013
Shahrdad Lotfipour
1Department of Psychiatry and Biobehavioral Sciences, Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90024,
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Janet S. Byun
1Department of Psychiatry and Biobehavioral Sciences, Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90024,
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Prescott Leach
2College of Liberal Arts, Temple University, Philadelphia, Pennsylvania 19122, and
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Christie D. Fowler
3Department of Molecular Therapeutics, Scripps Research Institute Florida, Jupiter, Florida 33458
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Niall P. Murphy
1Department of Psychiatry and Biobehavioral Sciences, Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90024,
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Paul J. Kenny
3Department of Molecular Therapeutics, Scripps Research Institute Florida, Jupiter, Florida 33458
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Thomas J. Gould
2College of Liberal Arts, Temple University, Philadelphia, Pennsylvania 19122, and
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Jim Boulter
1Department of Psychiatry and Biobehavioral Sciences, Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90024,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4731-12.2013
PubMed 
23637165
Published By 
Society for Neuroscience
History 
  • Received October 5, 2012
  • Revision received February 21, 2013
  • Accepted March 25, 2013
  • First published May 1, 2013.
  • Version of record published May 1, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/337728-14$15.00/0

Author Information

  1. Shahrdad Lotfipour1,
  2. Janet S. Byun1,
  3. Prescott Leach2,
  4. Christie D. Fowler3,
  5. Niall P. Murphy1,
  6. Paul J. Kenny3,
  7. Thomas J. Gould2, and
  8. Jim Boulter1
  1. 1Department of Psychiatry and Biobehavioral Sciences, Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90024,
  2. 2College of Liberal Arts, Temple University, Philadelphia, Pennsylvania 19122, and
  3. 3Department of Molecular Therapeutics, Scripps Research Institute Florida, Jupiter, Florida 33458
View Full Text

Author contributions

  1. Author contributions: S.L., J.S.B., P.L., C.D.F., P.J.K., T.J.G., and J.B. designed research; S.L., J.S.B., P.L., C.D.F., N.P.M., and J.B. performed research; S.L., J.S.B., N.P.M., P.J.K., T.J.G., and J.B. contributed unpublished reagents/analytic tools; S.L., J.S.B., P.L., C.D.F., N.P.M., P.J.K., T.J.G., and J.B. analyzed data; S.L. and J.B. wrote the paper.

Disclosures

    • Received October 5, 2012.
    • Revision received February 21, 2013.
    • Accepted March 25, 2013.
  • This work was supported by Tobacco-Related Disease Research Program Grant 10RT-0136 to J.B., UCLA Jonsson Cancer Center Foundation seed grant to J.B., Tobacco-Related Disease Research Program Fellowship 20FT-0072 to S.L., UCLA Friends of the Semel Institute (S.L.), T32 National Institute of Mental Health postdoctoral fellowship MH17140 to S.L., National Alliance for Research on Schizophrenia and Depression Young Investigator Award 17717 to S.L., a UCLA Molecular and Cellular Neurobiology training fellowship to J.S.B., National Institute on Drug Abuse Grant DA024787 to T.J.G., and National Institute on Drug Abuse Training Grant DA007237–23 to P.L. We thank Camron Bryant, Carlos Laszo, Kris Roberts, Rachel Poole, Michael Adoff, and Anna Taylor for their assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Shahrdad Lotfipour, UCLA MacDonald Research Laboratories, 675 Charles E. Young Drive South, Los Angeles, CA 90095. shahrdad{at}ucla.edu

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Apr 2013211
May 20131830104155
Jun 20131815328
Jul 20131685032
Aug 2013654021
Sep 2013591813
Oct 2013943521
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Total 20132504371338
Jan 2014533017
Feb 2014531319
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Apr 2014501520
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Jun 2014261911
Jul 2014322712
Aug 2014333320
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Total 2014488253184
Jan 2015273118
Feb 2015322110
Mar 2015402012
Apr 2015292211
May 2015241115
Jun 201535116
Jul 2015211510
Aug 201528139
Sep 201518135
Oct 201529199
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Dec 20153266
Total 2015345187117
Jan 2016171117
Feb 2016251410
Mar 2016361316
Apr 201624239
May 2016101511
Jun 2016241614
Jul 201613226
Aug 201624126
Sep 2016292312
Oct 201619228
Nov 2016101715
Dec 20163339
Total 2016234221133
Jan 2017143713
Feb 20176191
Mar 201742207
Apr 2017534216
May 2017630119
Jun 2017323412
Jul 201741216
Aug 20174156
Sep 20171135
Oct 201732815
Nov 201751311
Dec 20170247
Total 2017551367118
Jan 201843212
Feb 201812511
Mar 20183196
Apr 20187274
May 20184335
Jun 20182396
Jul 20186266
Aug 20182191
Sep 20180383
Oct 20181579
Nov 20186494
Dec 20181325
Total 20183739672
Jan 201972713
Feb 20197212
Mar 20198286
Apr 201992810
May 20199205
Jun 20193375
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Total 20197729496
Jan 20203247
Feb 2020276
Mar 20208199
Apr 20203144
May 2020276
Jun 20204169
Jul 20205153
Aug 20200102
Sep 202032310
Oct 202010299
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Dec 2020113914
Total 20205222087
Jan 20215244
Feb 20213179
Mar 202162717
Apr 202141111
May 20214194
Jun 202112310
Jul 20217139
Aug 20218115
Sep 202172015
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Dec 20212208
Total 202156221152
Jan 202221312
Feb 20225197
Mar 202241510
Apr 20229219
May 202241710
Jun 202272411
Jul 2022133
Total 20223211262
Total388036421359
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The Journal of Neuroscience: 33 (18)
Journal of Neuroscience
Vol. 33, Issue 18
1 May 2013
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Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors
Shahrdad Lotfipour, Janet S. Byun, Prescott Leach, Christie D. Fowler, Niall P. Murphy, Paul J. Kenny, Thomas J. Gould, Jim Boulter
Journal of Neuroscience 1 May 2013, 33 (18) 7728-7741; DOI: 10.1523/JNEUROSCI.4731-12.2013

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Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors
Shahrdad Lotfipour, Janet S. Byun, Prescott Leach, Christie D. Fowler, Niall P. Murphy, Paul J. Kenny, Thomas J. Gould, Jim Boulter
Journal of Neuroscience 1 May 2013, 33 (18) 7728-7741; DOI: 10.1523/JNEUROSCI.4731-12.2013
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