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Articles, Development/Plasticity/Repair

Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury

Chhavy Tep, Tae Hee Lim, Pyung On Ko, Sami Getahun, Jae Cheon Ryu, Virginia M. Goettl, Stephen M. Massa, Michele Basso, Frank M. Longo and Sung Ok Yoon
Journal of Neuroscience 9 January 2013, 33 (2) 397-410; DOI: https://doi.org/10.1523/JNEUROSCI.0399-12.2013
Chhavy Tep
1Departments of Molecular and Cellular Biochemistry, and
3Biochemistry Program, The Ohio State University, Columbus, Ohio 43210,
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Tae Hee Lim
1Departments of Molecular and Cellular Biochemistry, and
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Pyung On Ko
1Departments of Molecular and Cellular Biochemistry, and
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Sami Getahun
1Departments of Molecular and Cellular Biochemistry, and
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Jae Cheon Ryu
1Departments of Molecular and Cellular Biochemistry, and
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Virginia M. Goettl
1Departments of Molecular and Cellular Biochemistry, and
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Stephen M. Massa
4Department of Neurology, University of California at San Francisco, San Francisco, California 94121, and
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Michele Basso
2Physical Therapy, and
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Frank M. Longo
5Department of Neurology and Neurological Science, Stanford University, Stanford, California 94305
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Sung Ok Yoon
1Departments of Molecular and Cellular Biochemistry, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0399-12.2013
PubMed 
23303920
Published By 
Society for Neuroscience
History 
  • Received January 27, 2012
  • Revision received October 16, 2012
  • Accepted October 18, 2012
  • First published January 9, 2013.
  • Version of record published January 9, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/330397-14$15.00/0

Author Information

  1. Chhavy Tep1,3,
  2. Tae Hee Lim1,
  3. Pyung On Ko1,
  4. Sami Getahun1,
  5. Jae Cheon Ryu1,
  6. Virginia M. Goettl1,
  7. Stephen M. Massa4,
  8. Michele Basso2,
  9. Frank M. Longo5, and
  10. Sung Ok Yoon1
  1. 1Departments of Molecular and Cellular Biochemistry, and
  2. 2Physical Therapy, and
  3. 3Biochemistry Program, The Ohio State University, Columbus, Ohio 43210,
  4. 4Department of Neurology, University of California at San Francisco, San Francisco, California 94121, and
  5. 5Department of Neurology and Neurological Science, Stanford University, Stanford, California 94305
View Full Text

Author contributions

  1. Author contributions: C.T. and S.O.Y. designed research; C.T., T.H.L., P.O.K., S.G., J.C.R., and V.M.G. performed research; S.M.M. and M.B. contributed unpublished reagents/analytic tools; C.T., F.M.L., and S.O.Y. analyzed data; C.T., F.M.L., and S.O.Y. wrote the paper.

Disclosures

    • Received January 27, 2012.
    • Revision received October 16, 2012.
    • Accepted October 18, 2012.
  • This work was funded by grants from the National Institute of Neurological Disorders and Stroke (NINDS) (RO1NS050585, R21NS059503) and the Christopher and Dana Reeve Foundation to S.O.Y., and The Ohio State Neuroscience Center Core from NINDS (P30NS045758). We thank Drs. Barbara Hempstead, Bruce Carter, and Elizabeth Coulson for providing p75 knock-out mice.

  • F.M.L. is a founder of PharmatrophiX, a company focused on the development of neurotrophin receptor ligands.

  • Correspondence should be addressed to Dr. Sung Ok Yoon, Department of Molecular and Cellular Biochemistry, 184 Rightmire Hall, Ohio State University, 1060 Carmack Road, Columbus, OH 43210. Sung.yoon{at}osumc.edu

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AbstractFullPdf
Jan 20133818207643
Feb 201352284114
Mar 20133154576
Apr 20132724131
May 20131904329
Jun 20131362418
Jul 20131353735
Aug 20131146435
Sep 20131973227
Oct 20132034730
Nov 20132214834
Dec 20131543530
Total 201362777071102
Jan 20141425945
Feb 20141072520
Mar 20141042916
Apr 20141072532
May 2014773427
Jun 2014763521
Jul 2014843416
Aug 2014632820
Sep 2014832613
Oct 2014943213
Nov 2014953010
Dec 2014753013
Total 20141107387246
Jan 2015663818
Feb 2015712114
Mar 2015832114
Apr 2015494915
May 201556157
Jun 2015362321
Jul 20156189
Aug 201531146
Sep 2015902273
Oct 2015671011
Nov 20157074
Dec 2015522120
Total 2015732249212
Jan 2016541410
Feb 2016553815
Mar 2016392221
Apr 2016521610
May 201651911
Jun 20163469
Jul 2016351410
Aug 201625117
Sep 2016191310
Oct 2016351213
Nov 2016142110
Dec 20163167
Total 2016416192133
Jan 20174249
Feb 20176398
Mar 20172268
Apr 201722027
May 201732612
Jun 20172114
Jul 20172178
Aug 20175119
Sep 20175171
Oct 20171275
Nov 20172268
Dec 20172303
Total 201736274102
Jan 20183346
Feb 20185171
Mar 20182248
Apr 20183254
May 20182273
Jun 20182288
Jul 20182206
Aug 20181257
Sep 20181203
Oct 20184322
Nov 20183223
Dec 20180233
Total 20182829754
Jan 20197183
Feb 20192184
Mar 20192114
Apr 20194239
May 20197173
Jun 20196188
Jul 20191166
Aug 20193166
Sep 20196378
Oct 20193789
Nov 201931014
Dec 20196215
Total 20195028379
Jan 20207212
Feb 20202229
Mar 20203178
Apr 20202814
May 2020111518
Jun 20202136
Jul 2020272
Aug 2020172
Sep 202051049
Oct 202048612
Nov 202045022
Dec 202073010
Total 202050380114
Jan 20215558
Feb 202123515
Mar 202175924
Apr 202173511
May 20214265
Jun 20215239
Jul 202151715
Aug 202132227
Sep 202142225
Oct 202154225
Nov 202111922
Dec 20212157
Total 202150370193
Jan 202243017
Feb 20220261
Mar 20222159
Apr 202210149
May 202214013
Total 20221712549
Total876332642284
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The Journal of Neuroscience: 33 (2)
Journal of Neuroscience
Vol. 33, Issue 2
9 Jan 2013
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Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury
Chhavy Tep, Tae Hee Lim, Pyung On Ko, Sami Getahun, Jae Cheon Ryu, Virginia M. Goettl, Stephen M. Massa, Michele Basso, Frank M. Longo, Sung Ok Yoon
Journal of Neuroscience 9 January 2013, 33 (2) 397-410; DOI: 10.1523/JNEUROSCI.0399-12.2013

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Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury
Chhavy Tep, Tae Hee Lim, Pyung On Ko, Sami Getahun, Jae Cheon Ryu, Virginia M. Goettl, Stephen M. Massa, Michele Basso, Frank M. Longo, Sung Ok Yoon
Journal of Neuroscience 9 January 2013, 33 (2) 397-410; DOI: 10.1523/JNEUROSCI.0399-12.2013
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