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Articles, Systems/Circuits

Functional Circuits and Anatomical Distribution of Response Properties in the Primate Amygdala

Wujie Zhang, David M. Schneider, Marina A. Belova, Sara E. Morrison, Joseph J. Paton and C. Daniel Salzman
Journal of Neuroscience 9 January 2013, 33 (2) 722-733; DOI: https://doi.org/10.1523/JNEUROSCI.2970-12.2013
Wujie Zhang
1Departments of Neuroscience and
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David M. Schneider
1Departments of Neuroscience and
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Marina A. Belova
1Departments of Neuroscience and
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Sara E. Morrison
1Departments of Neuroscience and
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Joseph J. Paton
1Departments of Neuroscience and
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C. Daniel Salzman
1Departments of Neuroscience and
2Psychiatry,
3W.M. Keck Center on Brain Plasticity and Cognition,
4Kavli Institute for Brain Sciences, and
5Mahoney Center for Brain and Behavior, Columbia University, and
6New York State Psychiatric Institute, New York, New York 10032
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Abstract

Recent electrophysiological studies on the primate amygdala have advanced our understanding of how individual neurons encode information relevant to emotional processes, but it remains unclear how these neurons are functionally and anatomically organized. To address this, we analyzed cross-correlograms of amygdala spike trains recorded during a task in which monkeys learned to associate novel images with rewarding and aversive outcomes. Using this task, we have recently described two populations of amygdala neurons: one that responds more strongly to images predicting reward (positive value-coding), and another that responds more strongly to images predicting an aversive stimulus (negative value-coding). Here, we report that these neural populations are organized into distinct, but anatomically intermingled, appetitive and aversive functional circuits, which are dynamically modulated as animals used the images to predict outcomes. Furthermore, we report that responses to sensory stimuli are prevalent in the lateral amygdala, and are also prevalent in the medial amygdala for sensory stimuli that are emotionally significant. The circuits identified here could potentially mediate valence-specific emotional behaviors thought to involve the amygdala.

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The Journal of Neuroscience: 33 (2)
Journal of Neuroscience
Vol. 33, Issue 2
9 Jan 2013
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Functional Circuits and Anatomical Distribution of Response Properties in the Primate Amygdala
Wujie Zhang, David M. Schneider, Marina A. Belova, Sara E. Morrison, Joseph J. Paton, C. Daniel Salzman
Journal of Neuroscience 9 January 2013, 33 (2) 722-733; DOI: 10.1523/JNEUROSCI.2970-12.2013

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Functional Circuits and Anatomical Distribution of Response Properties in the Primate Amygdala
Wujie Zhang, David M. Schneider, Marina A. Belova, Sara E. Morrison, Joseph J. Paton, C. Daniel Salzman
Journal of Neuroscience 9 January 2013, 33 (2) 722-733; DOI: 10.1523/JNEUROSCI.2970-12.2013
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