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Brief Communications

EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability

Kunpeng Zhao, Ruojian Wen, Xiaoxi Wang, Lei Pei, Ying Yang, You Shang, Nicolas Bazan, Ling-Qiang Zhu, Qing Tian and Youming Lu
Journal of Neuroscience 15 May 2013, 33 (20) 8861-8865; DOI: https://doi.org/10.1523/JNEUROSCI.5686-12.2013
Kunpeng Zhao
1Key Laboratory of Neurological Disease, Ministry of Education, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430030 China,
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Ruojian Wen
1Key Laboratory of Neurological Disease, Ministry of Education, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430030 China,
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Xiaoxi Wang
1Key Laboratory of Neurological Disease, Ministry of Education, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430030 China,
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Lei Pei
1Key Laboratory of Neurological Disease, Ministry of Education, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430030 China,
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Ying Yang
1Key Laboratory of Neurological Disease, Ministry of Education, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430030 China,
3Neuroscience Center of Excellence and Department of Neurology, Louisiana State University School of Medicine, New Orleans, Louisiana 70112
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You Shang
2Translational Research Center, the Union Hospital, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430022 China, and
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Nicolas Bazan
3Neuroscience Center of Excellence and Department of Neurology, Louisiana State University School of Medicine, New Orleans, Louisiana 70112
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Ling-Qiang Zhu
1Key Laboratory of Neurological Disease, Ministry of Education, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430030 China,
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Qing Tian
1Key Laboratory of Neurological Disease, Ministry of Education, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430030 China,
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Youming Lu
1Key Laboratory of Neurological Disease, Ministry of Education, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430030 China,
2Translational Research Center, the Union Hospital, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430022 China, and
3Neuroscience Center of Excellence and Department of Neurology, Louisiana State University School of Medicine, New Orleans, Louisiana 70112
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5686-12.2013
PubMed 
23678128
Published By 
Society for Neuroscience
History 
  • Received December 13, 2012
  • Revision received February 10, 2013
  • Accepted February 15, 2013
  • First published May 15, 2013.
  • Version of record published May 15, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/338861-05$15.00/0

Author Information

  1. Kunpeng Zhao1,*,
  2. Ruojian Wen1,*,
  3. Xiaoxi Wang1,
  4. Lei Pei1,
  5. Ying Yang1,3,
  6. You Shang2,
  7. Nicolas Bazan3,
  8. Ling-Qiang Zhu1,
  9. Qing Tian1, and
  10. Youming Lu1,2,3
  1. 1Key Laboratory of Neurological Disease, Ministry of Education, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430030 China,
  2. 2Translational Research Center, the Union Hospital, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430022 China, and
  3. 3Neuroscience Center of Excellence and Department of Neurology, Louisiana State University School of Medicine, New Orleans, Louisiana 70112
View Full Text

Author contributions

  1. Author contributions: R.W., L.-Q.Z., Q.T., and Y.L. designed research; K.Z., R.W., X.W., L.P., Y.Y., and Y.S. performed research; K.Z., N.B., L.-Q.Z., Q.T., and Y.L. analyzed data; K.Z., R.W., L.-Q.Z., Q.T., and Y.L. wrote the paper.

  2. ↵*K.Z. and R.W. contributed equally to this work.

Disclosures

    • Received December 13, 2012.
    • Revision received February 10, 2013.
    • Accepted February 15, 2013.
  • This work was supported by National Natural Science Foundation of China (Grants 81130079 and 91232302 to Y.L., 81200863 to L.P., and 81271404 to Q.T.), New Century Excellent Talent (Grant NCET-10-0241 to L.-Q.Z.), Ministry of Science and Technology of China (Grant 2011DFG33250 to L.-Q.Z.), and the National Institute on Aging–National Institutes of Health (Grant R01AG033282 to Y.L.).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to one of the following: Ling-Qiang Zhu, Qing Tian, or Youming Lu, Key Laboratory of Neurological Disease, Ministry of Education, Huazhong University of Science and Technology Tongji Medical College, Wuhan, 430030 China. zhulq{at}mail.hust.edu.cn, tianq{at}mail.hust.edu.cn, or lym{at}mail.hust.edu.cn

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May 20133278137161
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Jul 20131262524
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Total 2016137209134
Jan 201782112
Feb 201742720
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Apr 201772710
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Jun 20172207
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Aug 20170155
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Total 201745245103
Jan 20181133
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Feb 2019453
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Total 202037164124
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Feb 20218134
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Apr 20217145
May 2021121310
Jun 20219149
Jul 2021587
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Total 202185182141
Jan 202221911
Feb 20222134
Mar 20222288
Apr 20222217
May 2022269
Total 2022108739
Total496920371368
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The Journal of Neuroscience: 33 (20)
Journal of Neuroscience
Vol. 33, Issue 20
15 May 2013
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EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability
Kunpeng Zhao, Ruojian Wen, Xiaoxi Wang, Lei Pei, Ying Yang, You Shang, Nicolas Bazan, Ling-Qiang Zhu, Qing Tian, Youming Lu
Journal of Neuroscience 15 May 2013, 33 (20) 8861-8865; DOI: 10.1523/JNEUROSCI.5686-12.2013

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EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability
Kunpeng Zhao, Ruojian Wen, Xiaoxi Wang, Lei Pei, Ying Yang, You Shang, Nicolas Bazan, Ling-Qiang Zhu, Qing Tian, Youming Lu
Journal of Neuroscience 15 May 2013, 33 (20) 8861-8865; DOI: 10.1523/JNEUROSCI.5686-12.2013
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