Article Information
- Received December 11, 2012
- Revision received March 6, 2013
- Accepted March 30, 2013
- First published May 22, 2013.
- Version of record published May 22, 2013.
Author Information
- Johannes Gräff1,2,
- Martin Kahn1,
- Alireza Samiei1,
- Jun Gao1,
- Kristie T. Ota1,
- Damien Rei1,2, and
- Li-Huei Tsai1,2,3
- 1Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences and
- 2Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and
- 3Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142
Author contributions
Author contributions: J. Gräff, D.R., and L.-H.T. designed research; J. Gräff, M.K., A.S., J. Gao, K.T.O., and D.R. performed research; L.-H.T. contributed unpublished reagents/analytic tools; J. Gräff, M.K., J. Gao, K.T.O., and L.-H.T. analyzed data; J. Gräff and L.-H.T. wrote the paper.
Disclosures
- Received December 11, 2012.
- Revision received March 6, 2013.
- Accepted March 30, 2013.
This work was supported by a Swiss National Science Foundation Grant for Prospective Researchers (J. Gräff), the Theodor and Ida Herzog-Egli Foundation (M.K.), and the Glenn Foundation for Medical Research and NIH Grant PO1 AG027916 (L.-H.T.). L.-H.T. is an HHMI investigator. We thank Vipin X. Suri and Jim Ellis from Sirtris-GSK for the SRT3657 compound, Maria Ericsson for the electron microscopy experiments, Katie Schlieper and Mali Taylor for mouse colony maintenance and the oral gavage, Alison Mungenast for text editing, and Matthew M. Dobbin for fruitful scientific discussions. Sirtris Pharmaceuticals contributed to this study in providing and characterizing SRT3657 under a material transfer agreement.
L.-H.T. is a scientific advisor of Sirtris-GSK.
- Correspondence should be addressed to Li-Huei Tsai at the above address. lhtsai{at}mit.edu
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