The Class 4 Semaphorin Sema4D Promotes the Rapid Assembly of GABAergic Synapses in Rodent Hippocampus

Article Information

DOI

PubMed

Published By

History

¹Department of Biology, National Center for Behavioral Genomics, and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, and
²Department of Neuroscience, Neurosurgery, and Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029

Author contributions: M.S.K., A.R.M., R.H.F., and S.P. designed research; M.S.K., A.R.M., and E.K.S. performed research; R.H.F. contributed unpublished reagents/analytic tools; M.S.K., A.R.M., and E.K.S. analyzed data; M.S.K., A.R.M., and S.P. wrote the paper.
↵*M.S.K. and A.R.M. contributed equally to this work.

This work was supported in part by the March of Dimes (Research Grant #5-FY09-125), the National Institutes of Health (Grant #R01NS065856 to S.P. and Grant #F31NS078901 to M.S.K.; A.R.M. supported by Grant #T32NS007292 to Eve Marder), and Core Facilities for Neurobiology at Brandeis University (Grant #P30NS45713). We thank Dr. Alain Chedotal for the gift of the Sema4D-AP construct, Dr. Marc Tessier-Lavigne for the gift of the PlexinB1^−/− mice, and Drs. Paul Garrity and Sacha Nelson for experimental advice and critical reading of this manuscript.
M.S.K., A.R.M. and S.P. are listed as coinventors on a provisional patent application entitled “Methods of Modulating GABAergic Inhibitory Synapse Formation and Function Using Sema4D.” The remaining authors declare no competing financial interests.
Correspondence should be addressed to Suzanne Paradis, Department of Biology, National Center for Behavioral Genomics, and Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454. paradis{at}brandeis.edu

Select a custom date range for the past year