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Articles, Neurobiology of Disease

MHCII Is Required for α-Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration

Ashley S. Harms, Shuwen Cao, Amber L. Rowse, Aaron D. Thome, Xinru Li, Leandra R. Mangieri, Randy Q. Cron, John J. Shacka, Chander Raman and David G. Standaert
Journal of Neuroscience 5 June 2013, 33 (23) 9592-9600; https://doi.org/10.1523/JNEUROSCI.5610-12.2013
Ashley S. Harms
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology,
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Shuwen Cao
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology,
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Amber L. Rowse
2Department of Microbiology, and
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Aaron D. Thome
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology,
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Xinru Li
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology,
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Leandra R. Mangieri
3Department of Pathology, Neuropathology Division, The University of Alabama at Birmingham, Birmingham, Alabama 35294,
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Randy Q. Cron
4Department of Pediatrics, Division of Rheumatology, Children's Hospital of Alabama, Birmingham, Alabama 35294,
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John J. Shacka
3Department of Pathology, Neuropathology Division, The University of Alabama at Birmingham, Birmingham, Alabama 35294,
5The Birmingham VA Medical Center, Birmingham, Alabama 35294, and
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Chander Raman
6Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294
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David G. Standaert
1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5610-12.2013
PubMed 
23739956
Published By 
Society for Neuroscience
History 
  • Received December 7, 2012
  • Revision received March 27, 2013
  • Accepted April 16, 2013
  • First published June 5, 2013.
  • Version of record published June 5, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/339592-09$15.00/0

Author Information

  1. Ashley S. Harms1,
  2. Shuwen Cao1,
  3. Amber L. Rowse2,
  4. Aaron D. Thome1,
  5. Xinru Li1,
  6. Leandra R. Mangieri3,
  7. Randy Q. Cron4,
  8. John J. Shacka3,5,
  9. Chander Raman6, and
  10. David G. Standaert1
  1. 1Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology,
  2. 2Department of Microbiology, and
  3. 3Department of Pathology, Neuropathology Division, The University of Alabama at Birmingham, Birmingham, Alabama 35294,
  4. 4Department of Pediatrics, Division of Rheumatology, Children's Hospital of Alabama, Birmingham, Alabama 35294,
  5. 5The Birmingham VA Medical Center, Birmingham, Alabama 35294, and
  6. 6Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294
View Full Text

Author contributions

  1. Author contributions: A.S.H., S.C., A.L.R., R.Q.C., J.J.S., C.R., and D.G.S. designed research; A.S.H., S.C., A.L.R., A.D.T., X.L., L.R.M., and J.J.S. performed research; C.R. and D.G,S. contributed unpublished reagents/analytic tools; A.S.H., S.C., A.L.R., L.R.M., and C.R. analyzed data; A.S.H., S.C., A.L.R., A.D.T., R.Q.C., J.J.S., C.R., and D.G.S. wrote the paper.

Disclosures

    • Received December 7, 2012.
    • Revision received March 27, 2013.
    • Accepted April 16, 2013.
  • The work from these studies is generously supported by the RJG Foundation, the University of Alabama (UAB) Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center (CAMAC) Comprehensive Flow Cytometry Core (NIH Grant P30 AR48311), the UAB Animal Resources Program (NIH Grants G20 RR025858 and G20 RR022807-01), and NIH Grant T32 AR007450-30. We thank Dr. Chad Steele for his help with the multiplex ELISA assay at University of Alabama at Birmingham.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. David G. Standaert, Professor and Chair of Neurology, John N. Whitaker Endowed Chair, Director, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 516, Birmingham, AL 35294-0021. dstandaert{at}uab.edu

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The Journal of Neuroscience: 33 (23)
Journal of Neuroscience
Vol. 33, Issue 23
5 Jun 2013
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MHCII Is Required for α-Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration
Ashley S. Harms, Shuwen Cao, Amber L. Rowse, Aaron D. Thome, Xinru Li, Leandra R. Mangieri, Randy Q. Cron, John J. Shacka, Chander Raman, David G. Standaert
Journal of Neuroscience 5 June 2013, 33 (23) 9592-9600; DOI: 10.1523/JNEUROSCI.5610-12.2013

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MHCII Is Required for α-Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration
Ashley S. Harms, Shuwen Cao, Amber L. Rowse, Aaron D. Thome, Xinru Li, Leandra R. Mangieri, Randy Q. Cron, John J. Shacka, Chander Raman, David G. Standaert
Journal of Neuroscience 5 June 2013, 33 (23) 9592-9600; DOI: 10.1523/JNEUROSCI.5610-12.2013
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