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Activation of NF-κB in Schwann Cells Is Dispensable for Myelination In Vivo
Paul D. Morton, Anna Dellarole, Michelle H. Theus, Winston M. Walters, Summer S. Berge and John R. Bethea
Journal of Neuroscience 12 June 2013, 33 (24) 9932-9936; DOI: https://doi.org/10.1523/JNEUROSCI.2483-12.2013
Paul D. Morton
1The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida 33136,
2Department of Neurosurgery, Miller School of Medicine, University of Miami, Miami, Florida 33136,
Anna Dellarole
1The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida 33136,
2Department of Neurosurgery, Miller School of Medicine, University of Miami, Miami, Florida 33136,
Michelle H. Theus
3Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061, and
Winston M. Walters
1The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida 33136,
2Department of Neurosurgery, Miller School of Medicine, University of Miami, Miami, Florida 33136,
Summer S. Berge
1The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida 33136,
John R. Bethea
1The Miami Project To Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida 33136,
2Department of Neurosurgery, Miller School of Medicine, University of Miami, Miami, Florida 33136,
4Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida 33136

Abstract
Peripheral myelination is a dynamic process orchestrated by axons and Schwann cells. Although the signaling mechanisms governing myelination are not fully understood, NF-κB activation in Schwann cells has been implicated as a key regulator in vitro. Using a mouse model, we show that nuclear factor κB activation in Schwann cells is not required for myelination in vivo.
In this issue
Journal of Neuroscience
Vol. 33, Issue 24
12 Jun 2013
Activation of NF-κB in Schwann Cells Is Dispensable for Myelination In Vivo
Paul D. Morton, Anna Dellarole, Michelle H. Theus, Winston M. Walters, Summer S. Berge, John R. Bethea
Journal of Neuroscience 12 June 2013, 33 (24) 9932-9936; DOI: 10.1523/JNEUROSCI.2483-12.2013
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