Cover legend: Portion of lobule VII of cerebellum from the mouse model of the lysosomal disease, late-infantile neuronal ceroid lipofuscinosis (CLN2 disease). Immunofluorescence labeling shows calbindin-positive Purkinje cells (red) and DAPI-labeled nuclei (blue) in relation to aberrant accumulation of the macroautophagy adapter protein p62/Sqstm1 (green) in protein aggregates. p62 responds to lysosomal membrane permeability in CLN2 disease by sequestering released lysosomal content in intraneuronal aggregates. Image generated by M. C. Micsenyi. For more information, see Micsenyi et al. (pages 10815–10827).