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Articles, Development/Plasticity/Repair

Nerve Regeneration Restores Supraspinal Control of Bladder Function after Complete Spinal Cord Injury

Yu-Shang Lee, Ching-Yi Lin, Hai-Hong Jiang, Marc DePaul, Vernon W. Lin and Jerry Silver
Journal of Neuroscience 26 June 2013, 33 (26) 10591-10606; DOI: https://doi.org/10.1523/JNEUROSCI.1116-12.2013
Yu-Shang Lee
1Departments of Neurosciences,
3Physical Medicine and Rehabilitation and
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Ching-Yi Lin
1Departments of Neurosciences,
3Physical Medicine and Rehabilitation and
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Hai-Hong Jiang
2Biomedical Engineering, and
4Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, and
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Marc DePaul
5Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106
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Vernon W. Lin
3Physical Medicine and Rehabilitation and
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Jerry Silver
5Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106
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Abstract

A life-threatening disability after complete spinal cord injury is urinary dysfunction, which is attributable to lack of regeneration of supraspinal pathways that control the bladder. Although numerous strategies have been proposed that can promote the regrowth of severed axons in the adult CNS, at present, the approaches by which this can be accomplished after complete cord transection are quite limited. In the present study, we modified a classic peripheral nerve grafting technique with the use of chondroitinase to facilitate the regeneration of axons across and beyond an extensive thoracic spinal cord transection lesion in adult rats. The novel combination treatment allows for remarkably lengthy regeneration of certain subtypes of brainstem and propriospinal axons across the injury site and is followed by markedly improved urinary function. Our studies provide evidence that an enhanced nerve grafting strategy represents a potential regenerative treatment after severe spinal cord injury.

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The Journal of Neuroscience: 33 (26)
Journal of Neuroscience
Vol. 33, Issue 26
26 Jun 2013
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Nerve Regeneration Restores Supraspinal Control of Bladder Function after Complete Spinal Cord Injury
Yu-Shang Lee, Ching-Yi Lin, Hai-Hong Jiang, Marc DePaul, Vernon W. Lin, Jerry Silver
Journal of Neuroscience 26 June 2013, 33 (26) 10591-10606; DOI: 10.1523/JNEUROSCI.1116-12.2013

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Nerve Regeneration Restores Supraspinal Control of Bladder Function after Complete Spinal Cord Injury
Yu-Shang Lee, Ching-Yi Lin, Hai-Hong Jiang, Marc DePaul, Vernon W. Lin, Jerry Silver
Journal of Neuroscience 26 June 2013, 33 (26) 10591-10606; DOI: 10.1523/JNEUROSCI.1116-12.2013
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