Transcranial Alternating Current Stimulation Modulates Large-Scale Cortical Network Activity by Network Resonance

Mohsin M. Ali; Kristin K. Sellers; Flavio Fröhlich

doi:10.1523/JNEUROSCI.5867-12.2013

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.5867-12.2013

PubMed

23825429

Published By

Society for Neuroscience

History

Received December 21, 2012
Revision received May 24, 2013
Accepted May 30, 2013
First published July 3, 2013.

Version of record published July 3, 2013.

Author Information

Mohsin M. Ali¹,⁶,⁷,
Kristin K. Sellers¹,⁴, and
Flavio Fröhlich¹,²,³,⁵

¹Departments of Psychiatry,
²Cell Biology and Physiology, and
³Biomedical Engineering,
⁴Neurobiology Curriculum, and
⁵Neuroscience Center, and
⁶Departments of Computer Science and
⁷Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599

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Author contributions

Author contributions: M.M.A. and F.F. designed research; M.M.A., K.K.S., and F.F. performed research; M.M.A., K.K.S., and F.F. analyzed data; M.M.A., K.K.S., and F.F. wrote the paper.

Disclosures

Received December 21, 2012.
Revision received May 24, 2013.
Accepted May 30, 2013.

This research was supported by the University of North Carolina (UNC) Department of Psychiatry, the UNC School of Medicine, and the Foundation of Hope. The authors thank Stephen Groner for help with the initial code development; Davis Bennett for help with the manuscript; Dr. Jan Prins for expert advice on parallel computing; and the UNC Scientific Computing group, in particular Dr. Mark Reed, for support with GPU-based high-performance computing.
The authors declare no competing financial interests.
Correspondence should be addressed to Flavio Frohlich, 115 Mason Farm Road, NRB 4109F, Chapel Hill, NC 27599. flavio_frohlich{at}med.unc.edu

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	Abstract	Full	Pdf
Jul 2013	2268	132	357
Aug 2013	147	42	62
Sep 2013	112	23	37
Oct 2013	149	33	42
Nov 2013	204	75	109
Dec 2013	114	57	32
Total 2013	2994	362	639
Jan 2014	98	68	73
Feb 2014	62	72	56
Mar 2014	58	82	49
Apr 2014	57	87	48
May 2014	57	118	63
Jun 2014	45	88	40
Jul 2014	62	65	40
Aug 2014	50	67	63
Sep 2014	40	68	88
Oct 2014	73	58	120
Nov 2014	38	48	123
Dec 2014	46	61	77
Total 2014	686	882	840
Jan 2015	53	127	109
Feb 2015	60	75	47
Mar 2015	66	78	119
Apr 2015	49	86	113
May 2015	45	75	47
Jun 2015	41	83	146
Jul 2015	45	80	93
Aug 2015	27	59	45
Sep 2015	46	57	46
Oct 2015	32	50	33
Nov 2015	52	64	46
Dec 2015	48	54	32
Total 2015	564	888	876
Jan 2016	38	56	40
Feb 2016	30	62	41
Mar 2016	41	48	97
Apr 2016	35	42	88
May 2016	55	50	83
Jun 2016	29	37	64
Jul 2016	52	30	58
Aug 2016	33	50	41
Sep 2016	48	77	49
Oct 2016	46	68	44
Nov 2016	19	53	60
Dec 2016	37	58	111
Total 2016	463	631	776
Jan 2017	31	97	33
Feb 2017	24	72	74
Mar 2017	27	91	40
Apr 2017	28	58	54
May 2017	24	76	37
Jun 2017	21	52	38
Jul 2017	25	69	26
Aug 2017	17	42	39
Sep 2017	20	48	24
Oct 2017	22	47	33
Nov 2017	16	50	35
Dec 2017	23	53	57
Total 2017	278	755	490
Jan 2018	21	67	70
Feb 2018	11	66	44
Mar 2018	2	62	46
Apr 2018	3	73	39
May 2018	3	68	38
Jun 2018	8	79	42
Jul 2018	0	62	30
Aug 2018	0	54	30
Sep 2018	6	59	21
Oct 2018	1	85	40
Nov 2018	0	97	38
Dec 2018	1	92	24
Total 2018	56	864	462
Jan 2019	2	79	40
Feb 2019	1	94	43
Mar 2019	4	96	51
Apr 2019	4	78	53
May 2019	6	83	64
Jun 2019	4	105	63
Jul 2019	1	61	37
Aug 2019	6	53	24
Sep 2019	5	66	33
Oct 2019	1	97	52
Nov 2019	5	65	27
Dec 2019	2	71	17
Total 2019	41	948	504
Jan 2020	11	97	34
Feb 2020	22	60	27
Mar 2020	17	52	24
Apr 2020	33	77	53
May 2020	16	79	58
Jun 2020	17	49	93
Jul 2020	15	47	45
Aug 2020	22	35	25
Sep 2020	16	60	19
Oct 2020	19	62	27
Nov 2020	28	64	63
Dec 2020	26	38	30
Total 2020	242	720	498
Jan 2021	32	90	73
Feb 2021	16	60	32
Mar 2021	27	73	67
Apr 2021	20	49	29
May 2021	24	89	44
Jun 2021	21	60	37
Jul 2021	22	45	32
Aug 2021	21	61	42
Sep 2021	25	78	39
Oct 2021	22	86	48
Nov 2021	14	44	47
Total 2021	244	735	490
Total	5568	6785	5575