Article Information
- Received March 3, 2013
- Revision received May 11, 2013
- Accepted May 15, 2013
- First published July 10, 2013.
- Version of record published July 10, 2013.
Author Information
- 1Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, MGH-Simches Research Center, Boston, Massachusetts 02114,
- 2Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and
- 3Department of Neurology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115
Author contributions
Author contributions: J.S. and R.J.K. designed research; E.A.H., U.G., and T.T. performed research; E.A.H., J.S., and R.J.K. analyzed data; E.A.H., J.S., and R.J.K. wrote the paper.
Disclosures
- Received March 3, 2013.
- Revision received May 11, 2013.
- Accepted May 15, 2013.
This work was supported by the National Institute of Neurological Disorders and Stroke Grant R01NS041783 to J.S., National Institute of Neurological Disorders and Stroke Grant R01NS075346 to R.J.K., and the Alzheimer's Association (to J.S. and R.J.K.). E.A.H. was supported by National Institutes of Health Training Grant T32 AG000222-18. R.J.K. was supported by Pew Scholar and John Merck Scholar awards. We thank Dr. Alison Goate for the APP C99 construct, Dr. Raphael Kopan for the NotchΔE construct, and members of the J.S. and R.J.K. laboratories for helpful discussions.
The authors declare no competing financial interests.
- Correspondence should be addressed to Dr. Raymond J. Kelleher III, MGH-Simches Research Center, CPZN 6234, 185 Cambridge Street, Boston, MA 02114. kelleher{at}helix.mgh.harvard.edu
