Experiment 1 | | | | | | |
Adolescent saline | 161.5 ± 2.2 | 161.1 ± 2.3 | 177.0 ± 2.2 | 183.6 ± 2.5 | 191.6 ± 2.4 | 331.0 ± 5 |
Adolescent morphine | 164.7 ± 1.9 | 166.8 ± 2.2 | 171.6 ± 2.3 | 175.9 ± 2.3* | 179.6 ± 2.4* | 328.5 ± 5 |
Experiment 2 | | | | | | |
Adult saline | 247.6 ± 2.1 | 253.8 ± 1.1 | 260.2 ± 1.6 | 266.0 ± 1.7 | 271.3 ± 1.7 | 368.7 ± 4.3 |
Adult morphine | 252.1 ± 2.2 | 258.7 ± 2.5 | 264.3 ± 2.8 | 264.6 ± 2.8 | 265.0 ± 2.9* | 369.1 ± 6.4 |
Experiment 3 | | | | | | |
Adolescent saline + vehicle | 161.8 ± 2.5 | 167.6 ± 2.6 | 176.3 ± 2.6 | 183.1 ± 3.1 | 190.4 ± 3.2 | 432.1 ± 10 |
Adolescent morphine + vehicle | 158.8 ± 1.4 | 160.0 ± 1.4 | 163.3 ± 1.3* | 166.3 ± 1.6* | 169.5 ± 1.7* | 433.3 ± 10 |
Adolescent saline + ibudilast | 162.6 ± 1.8 | 168.8 ± 1.9 | 175.2 ± 1.9 | 180.9 ± 2.0 | 188.0 ± 2.0 | 408.1 ± 34 |
Adolescent morphine + ibudilast | 164.0 ± 1.4 | 164.5 ± 1.5 | 166.5 ± 1.9* | 168.5 ± 1.6* | 170.7 ± 1.7* | 425.6 ± 9 |