Cover legend: Representative electroencephaolgraphy (EEG) traces from adult mice treated with either a nonbinding scrambled control antisense oligonucleotide (ASO; top) or a tau reducing ASO (bottom) following infusion of the GABA-antagonist Picrotoxin into the left hippocampus. Reducing total tau protein expression in the adult hippocampus substantially reduces the normalized spike frequency in this chemically induced seizure model. For more information, see DeVos et al. (pages 12887–12897).