Goofy Coordinates the Acuity of Olfactory Signaling

This work was supported by a grant from RIKEN Brain Science Institute to Y.Y.; a grant from Exploratory Research for Advanced Technology (ERATO) Touhara Chemosensory Signal Project of the Japan Sciences and Technology Agency (JST) to K.T. and Y.Y.; a Grant-in-Aid for Scientific Research (B); (KAKENHI 16300105) to Y.Y.; a Scientific Research on Priority Areas Grant (Cellular Sensor: KAKENHI 21026032 and 18077001) to Y.Y. and K.T.; a Scientific Research on Innovative Areas Grant (Systems Molecular Ethology: KAKENNHI 23115723) to Y.Y. from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT); and a Research Fellowship for Young Scientists Grant from Japan Society for the Promotion of Science to S.K. We thank Charles Yokoyama and Alexandra V. Terashima for critical reading of the manuscript; Toshiaki Nakashiba for helpful advice on cDNA library construction and signal sequence trap screening; Koji Sato for help in EOG recording; Kenneth A. Jacobs for pSUC2T7M13ORI vector and YTK12 yeast strain; Takeshi Imai and Hitoshi Sakano for I7(WT)-ires-ECFP and I7(WT)-ires-dnPKA-ires-EYFP transgenic mice; Frank L. Margolis for anti-OMP antibody; Sachiko Mitsui and Miwa Kawasaki for technical assistance; Brain Science Institute (BSI) Research Resource Center for help in antibody production and generation/maintenance of transgenic and knock-out mice; and members of the Yoshihara laboratory for valuable discussions.