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Articles, Development/Plasticity/Repair

Hypoxia-Induced Developmental Delays of Inhibitory Interneurons Are Reversed by Environmental Enrichment in the Postnatal Mouse Forebrain

Mila Komitova, Dionysios Xenos, Natalina Salmaso, Kathy May Tran, Theresa Brand, Michael L. Schwartz, Laura Ment and Flora M. Vaccarino
Journal of Neuroscience 14 August 2013, 33 (33) 13375-13387; https://doi.org/10.1523/JNEUROSCI.5286-12.2013
Mila Komitova
1Child Study Center,
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Dionysios Xenos
1Child Study Center,
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Natalina Salmaso
1Child Study Center,
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Kathy May Tran
1Child Study Center,
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Theresa Brand
1Child Study Center,
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Michael L. Schwartz
2Department of Neurobiology, and
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Laura Ment
3Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520
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Flora M. Vaccarino
1Child Study Center,
2Department of Neurobiology, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5286-12.2013
PubMed 
23946395
Published By 
Society for Neuroscience
History 
  • Received November 13, 2012
  • Revision received June 14, 2013
  • Accepted July 8, 2013
  • First published August 14, 2013.
  • Version of record published August 14, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/3313375-13$15.00/0

Author Information

  1. Mila Komitova1,
  2. Dionysios Xenos1,*,
  3. Natalina Salmaso1,*,
  4. Kathy May Tran1,
  5. Theresa Brand1,
  6. Michael L. Schwartz2,
  7. Laura Ment3, and
  8. Flora M. Vaccarino1,2
  1. 1Child Study Center,
  2. 2Department of Neurobiology, and
  3. 3Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520
View Full Text

Author contributions

  1. Author contributions: M.K., L.M., and F.V. designed research; M.K., D.X., N.S., K.M.T., T.B., and M.L.S. performed research; M.K., D.X., N.S., K.M.T., and F.V. analyzed data; M.K. and F.V. wrote the paper.

  2. ↵*D.X. and N.S. contributed equally to this work.

Disclosures

    • Received November 13, 2012.
    • Revision received June 14, 2013.
    • Accepted July 8, 2013.
  • This work was supported by P01 NS062686-04 and R01 NS060750 from the National Institute of Neurological Disorders and Stroke. M.K. was supported by a fellowship from the Swedish Brain Foundation (Hjarnfonden) and N.S. by a fellowship from the Fonds de Recherche en Sante du Quebec (2009–2012) and the Canadian Institute of Health Research (2012–present). We thank Drs. Charles Stiles and John Alberta at Dana Farber Cancer Institute, Boston, for their gift of Olig2 antibody and Dr. Kazuaki Yoshikawa at Osaka University, Japan, for his gift of Dlx-2 antibody. We thank Dr. Hanna Stevens and Dr. Karen Muller-Smith for useful discussions. Dr. George Anderson, Yale Child Study Center, is greatly acknowledged for technical advice about HPLC. We acknowledge Dr. Simone Tomasi, Elise Cheng, Suzannah Luft, Devon Fagel, and Dr. Teresa Sandoval-Minero for useful discussions and technical help.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Flora Vaccarino, Child Study Center, 230 South Frontage Road, New Haven, CT 06520. flora.vaccarino{at}yale.edu

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Jan 20184203
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Total 202565385138
Total52140031115
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The Journal of Neuroscience: 33 (33)
Journal of Neuroscience
Vol. 33, Issue 33
14 Aug 2013
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Hypoxia-Induced Developmental Delays of Inhibitory Interneurons Are Reversed by Environmental Enrichment in the Postnatal Mouse Forebrain
Mila Komitova, Dionysios Xenos, Natalina Salmaso, Kathy May Tran, Theresa Brand, Michael L. Schwartz, Laura Ment, Flora M. Vaccarino
Journal of Neuroscience 14 August 2013, 33 (33) 13375-13387; DOI: 10.1523/JNEUROSCI.5286-12.2013

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Hypoxia-Induced Developmental Delays of Inhibitory Interneurons Are Reversed by Environmental Enrichment in the Postnatal Mouse Forebrain
Mila Komitova, Dionysios Xenos, Natalina Salmaso, Kathy May Tran, Theresa Brand, Michael L. Schwartz, Laura Ment, Flora M. Vaccarino
Journal of Neuroscience 14 August 2013, 33 (33) 13375-13387; DOI: 10.1523/JNEUROSCI.5286-12.2013
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