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Brief Communications

Loss of NR1 Subunit of NMDARs in Primary Sensory Neurons Leads to Hyperexcitability and Pain Hypersensitivity: Involvement of Ca2+-Activated Small Conductance Potassium Channels

Promila Pagadala, Chul-Kyu Park, Sangsu Bang, Zheng-Zhong Xu, Rou-Gang Xie, Tong Liu, Bao-Xia Han, W. Daniel Tracey Jr, Fan Wang and Ru-Rong Ji
Journal of Neuroscience 14 August 2013, 33 (33) 13425-13430; https://doi.org/10.1523/JNEUROSCI.0454-13.2013
Promila Pagadala
1Departments of Cell Biology and Neurobiology and
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Chul-Kyu Park
2Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Sangsu Bang
2Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Zheng-Zhong Xu
2Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Rou-Gang Xie
2Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Tong Liu
2Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Bao-Xia Han
1Departments of Cell Biology and Neurobiology and
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W. Daniel Tracey Jr
1Departments of Cell Biology and Neurobiology and
2Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Fan Wang
1Departments of Cell Biology and Neurobiology and
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Ru-Rong Ji
2Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0454-13.2013
PubMed 
23946399
Published By 
Society for Neuroscience
History 
  • Received January 30, 2013
  • Revision received June 21, 2013
  • Accepted July 15, 2013
  • First published August 14, 2013.
  • Version of record published August 14, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/3313425-06$15.00/0

Author Information

  1. Promila Pagadala1,*,
  2. Chul-Kyu Park2,*,
  3. Sangsu Bang2,*,
  4. Zheng-Zhong Xu2,
  5. Rou-Gang Xie2,
  6. Tong Liu2,
  7. Bao-Xia Han1,
  8. W. Daniel Tracey Jr1,2,
  9. Fan Wang1, and
  10. Ru-Rong Ji2
  1. 1Departments of Cell Biology and Neurobiology and
  2. 2Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710
View Full Text

Author contributions

  1. Author contributions: P.P., C.-K.P., S.B., Z.-Z.X., T.L., F.W., and R.-R.J. designed research; P.P., C.-K.P., S.B., Z.-Z.X., R.-G.X., T.L., and B.-X.H. performed research; P.P., C.-K.P., S.B., Z.-Z.X., R.-G.X., T.L., and B.-X.H. analyzed data; W.D.T., F.W., and R.-R.J. wrote the paper.

  2. ↵*P.P., C.-K.P., and S.B. contributed equally to this work.

Disclosures

    • Received January 30, 2013.
    • Revision received June 21, 2013.
    • Accepted July 15, 2013.
  • The work was supported by the National Institutes of Health (Grants #RO1DE19440 and #RO1DE19440S1 to F.W., Grants #RO1DE17794, #RO1DE22743, and #RO1NS67686 to R.R.J., Grants #R01NS054899 and #R01GM086458 to W.D.T., and Grant #R21NS082985 to Z.Z.X.).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Ru-Rong Ji, Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Box DUMC 3094, Durham, NC 27010, ru-rong.ji{at}duke.edu; or Fan Wang, Departments of Cell Biology and Neurobiology, Duke University Medical Center, Box 3709, Durham, NC 27010, fan.wang{at}dm.duke.edu

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Jan 2018123214
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Total 202157225168
Jan 20222238
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Mar 202213714
Apr 20226286
May 202272617
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Jul 20225236
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Total 202245306120
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May 202363111
Jun 202342913
Jul 202333412
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The Journal of Neuroscience: 33 (33)
Journal of Neuroscience
Vol. 33, Issue 33
14 Aug 2013
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Loss of NR1 Subunit of NMDARs in Primary Sensory Neurons Leads to Hyperexcitability and Pain Hypersensitivity: Involvement of Ca2+-Activated Small Conductance Potassium Channels
Promila Pagadala, Chul-Kyu Park, Sangsu Bang, Zheng-Zhong Xu, Rou-Gang Xie, Tong Liu, Bao-Xia Han, W. Daniel Tracey Jr, Fan Wang, Ru-Rong Ji
Journal of Neuroscience 14 August 2013, 33 (33) 13425-13430; DOI: 10.1523/JNEUROSCI.0454-13.2013

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Loss of NR1 Subunit of NMDARs in Primary Sensory Neurons Leads to Hyperexcitability and Pain Hypersensitivity: Involvement of Ca2+-Activated Small Conductance Potassium Channels
Promila Pagadala, Chul-Kyu Park, Sangsu Bang, Zheng-Zhong Xu, Rou-Gang Xie, Tong Liu, Bao-Xia Han, W. Daniel Tracey Jr, Fan Wang, Ru-Rong Ji
Journal of Neuroscience 14 August 2013, 33 (33) 13425-13430; DOI: 10.1523/JNEUROSCI.0454-13.2013
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