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Articles, Behavioral/Cognitive

Delusions and the Role of Beliefs in Perceptual Inference

Katharina Schmack, Ana Gòmez-Carrillo de Castro, Marcus Rothkirch, Maria Sekutowicz, Hannes Rössler, John-Dylan Haynes, Andreas Heinz, Predrag Petrovic and Philipp Sterzer
Journal of Neuroscience 21 August 2013, 33 (34) 13701-13712; DOI: https://doi.org/10.1523/JNEUROSCI.1778-13.2013
Katharina Schmack
1Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany,
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Ana Gòmez-Carrillo de Castro
1Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany,
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Marcus Rothkirch
1Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany,
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Maria Sekutowicz
1Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany,
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Hannes Rössler
1Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany,
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John-Dylan Haynes
2Bernstein Center for Computational Neuroscience, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany,
3Graduate School of Mind and Brain, Humboldt-Universität zu Berlin, 10117 Berlin, Germany,
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Andreas Heinz
1Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany,
3Graduate School of Mind and Brain, Humboldt-Universität zu Berlin, 10117 Berlin, Germany,
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Predrag Petrovic
4Stockholm Brain Institute, 17177 Stockholm, Sweden, and
5Department of Clinical Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
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Philipp Sterzer
1Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany,
2Bernstein Center for Computational Neuroscience, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany,
3Graduate School of Mind and Brain, Humboldt-Universität zu Berlin, 10117 Berlin, Germany,
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Abstract

Delusions are unfounded yet tenacious beliefs and a symptom of psychotic disorder. Varying degrees of delusional ideation are also found in the healthy population. Here, we empirically validated a neurocognitive model that explains both the formation and the persistence of delusional beliefs in terms of altered perceptual inference. In a combined behavioral and functional neuroimaging study in healthy participants, we used ambiguous visual stimulation to probe the relationship between delusion-proneness and the effect of learned predictions on perception. Delusional ideation was associated with less perceptual stability, but a stronger belief-induced bias on perception, paralleled by enhanced functional connectivity between frontal areas that encoded beliefs and sensory areas that encoded perception. These findings suggest that weakened lower-level predictions that result in perceptual instability are implicated in the emergence of delusional beliefs. In contrast, stronger higher-level predictions that sculpt perception into conformity with beliefs might contribute to the tenacious persistence of delusional beliefs.

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The Journal of Neuroscience: 33 (34)
Journal of Neuroscience
Vol. 33, Issue 34
21 Aug 2013
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Delusions and the Role of Beliefs in Perceptual Inference
Katharina Schmack, Ana Gòmez-Carrillo de Castro, Marcus Rothkirch, Maria Sekutowicz, Hannes Rössler, John-Dylan Haynes, Andreas Heinz, Predrag Petrovic, Philipp Sterzer
Journal of Neuroscience 21 August 2013, 33 (34) 13701-13712; DOI: 10.1523/JNEUROSCI.1778-13.2013

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Delusions and the Role of Beliefs in Perceptual Inference
Katharina Schmack, Ana Gòmez-Carrillo de Castro, Marcus Rothkirch, Maria Sekutowicz, Hannes Rössler, John-Dylan Haynes, Andreas Heinz, Predrag Petrovic, Philipp Sterzer
Journal of Neuroscience 21 August 2013, 33 (34) 13701-13712; DOI: 10.1523/JNEUROSCI.1778-13.2013
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