MHCI Requires MEF2 Transcription Factors to Negatively Regulate Synapse Density during Development and in Disease

This work was funded by NINDS R01 NS060125 (A.K.M.), a grant from the UC Davis Research Investments in Science and Engineering Program (A.K.M.), and Dennis Weatherstone Predoctoral Fellowships (B.M.E. No. 6339 and M.L.E. No. 7825), and was supported by the National Center for Advancing Translational Sciences, NIH, through Grant UL1 TR 000002 and linked award TL1 TR 000133 (B.M.E.). We thank Drs. Stephanie Barrow, Samantha Spangler, Leigh Needleman, and Vlasta Lyles for generating neuronal cultures, and Drs. Needleman and Spangler for creating H2-Kb-YFP and H2-Kb-mCherry, respectively. Faten El-Sabeawy contributed valuable technical support. We would particularly like to thank Dr. Johannes Hell's lab at UC Davis for providing NS21 supplement. We would also like to thank the Flow Cytometry Shared Resource facility at UC Davis for their expertise and instrumentation. Drs. Chris Cowan, Mike Greenberg, and Mark Dell'Acqua provided valuable advice throughout the project.