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Brief Communications

MEK1/2 Inhibition Suppresses Tamoxifen Toxicity on CNS Glial Progenitor Cells

Hsing-Yu Chen, Yin Miranda Yang, Ruolan Han and Mark Noble
Journal of Neuroscience 18 September 2013, 33 (38) 15069-15074; https://doi.org/10.1523/JNEUROSCI.2729-13.2013
Hsing-Yu Chen
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642
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Yin Miranda Yang
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642
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Ruolan Han
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642
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Mark Noble
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2729-13.2013
PubMed 
24048837
Published By 
Society for Neuroscience
History 
  • Received June 27, 2013
  • Revision received July 31, 2013
  • Accepted August 5, 2013
  • First published September 18, 2013.
  • Version of record published September 18, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/3315069-06$15.00/0

Author Information

  1. Hsing-Yu Chen*,
  2. Yin Miranda Yang*,
  3. Ruolan Han, and
  4. Mark Noble
  1. Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642
  • Y. M. Yang's present address: Stemgent, 10575 Roselle Street San Diego, CA 92121.

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Author contributions

  1. Author contributions: H.-Y.C., Y.M.Y., and M.N. designed research; H.-Y.C., Y.M.Y., and R.H. performed research; H.-Y.C., Y.M.Y., and M.N. analyzed data; H.-Y.C. and M.N. wrote the paper.

  2. ↵*H.-Y.C. and Y.M.Y. contributed equally to this work.

  • Y. M. Yang's present address: Stemgent, 10575 Roselle Street San Diego, CA 92121.

Disclosures

    • Received June 27, 2013.
    • Revision received July 31, 2013.
    • Accepted August 5, 2013.
  • This work was supported by the National Institutes of Health (CA131385), the Department of Defense (W81XWH-07-1-060), the Susan G. Komen Race for the Cure Foundation, and the Carlson Stem Cell Fund. We thank Christoph Pröschel, Margot Mayer-Pröschel, Helene McMurray, Brett Stevens, and Craig Jordan for multiple helpful suggestions and critical discussions. We are also grateful to members of the Department of Biostatistics, in particular Olivier Hyrrien, for advice on all statistical analyses.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Mark Noble, Department of Biomedical Genetics, University of Rochester Medical Center, 575 Elmwood Avenue, Rochester, New York 14642. mark_noble{at}urmc.rochester.edu

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The Journal of Neuroscience: 33 (38)
Journal of Neuroscience
Vol. 33, Issue 38
18 Sep 2013
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MEK1/2 Inhibition Suppresses Tamoxifen Toxicity on CNS Glial Progenitor Cells
Hsing-Yu Chen, Yin Miranda Yang, Ruolan Han, Mark Noble
Journal of Neuroscience 18 September 2013, 33 (38) 15069-15074; DOI: 10.1523/JNEUROSCI.2729-13.2013

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MEK1/2 Inhibition Suppresses Tamoxifen Toxicity on CNS Glial Progenitor Cells
Hsing-Yu Chen, Yin Miranda Yang, Ruolan Han, Mark Noble
Journal of Neuroscience 18 September 2013, 33 (38) 15069-15074; DOI: 10.1523/JNEUROSCI.2729-13.2013
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