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Articles, Behavioral/Cognitive

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

Suresh D. Muthukumaraswamy, Robin L. Carhart-Harris, Rosalyn J. Moran, Matthew J. Brookes, Tim M. Williams, David Errtizoe, Ben Sessa, Andreas Papadopoulos, Mark Bolstridge, Krish D. Singh, Amanda Feilding, Karl J. Friston and David J. Nutt
Journal of Neuroscience 18 September 2013, 33 (38) 15171-15183; https://doi.org/10.1523/JNEUROSCI.2063-13.2013
Suresh D. Muthukumaraswamy
1Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF119BJ, United Kingdom,
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Robin L. Carhart-Harris
2Imperial College London, Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, London W12 ONN, United Kingdom,
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Rosalyn J. Moran
7Virginia Tech Carilion Research Institute, and Bradley Department of Electrical & Computer Engineering, Virginia Polytechnic Institute and State University, Roanoke, Virginia 24016
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Matthew J. Brookes
4Sir Peter Mansfield Magnetic Resonance Centre, Nottingham University, Nottingham NG7 2RD, United Kingdom,
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Tim M. Williams
5Academic Unit of Psychiatry, University of Bristol, Bristol BS8 2BN, United Kingdom,
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David Errtizoe
2Imperial College London, Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, London W12 ONN, United Kingdom,
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Ben Sessa
5Academic Unit of Psychiatry, University of Bristol, Bristol BS8 2BN, United Kingdom,
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Andreas Papadopoulos
5Academic Unit of Psychiatry, University of Bristol, Bristol BS8 2BN, United Kingdom,
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Mark Bolstridge
2Imperial College London, Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, London W12 ONN, United Kingdom,
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Krish D. Singh
1Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF119BJ, United Kingdom,
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Amanda Feilding
6The Beckley Foundation, Beckley Park, Oxford OX3 9SY, United Kingdom, and
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Karl J. Friston
3Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom,
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David J. Nutt
2Imperial College London, Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, London W12 ONN, United Kingdom,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2063-13.2013
PubMed 
24048847
Published By 
Society for Neuroscience
History 
  • Received May 13, 2013
  • Revision received August 5, 2013
  • Accepted August 8, 2013
  • First published September 18, 2013.
  • Version of record published September 18, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/3315171-13$15.00/0

Author Information

  1. Suresh D. Muthukumaraswamy1,*,
  2. Robin L. Carhart-Harris2,*,
  3. Rosalyn J. Moran7,
  4. Matthew J. Brookes4,
  5. Tim M. Williams5,
  6. David Errtizoe2,
  7. Ben Sessa5,
  8. Andreas Papadopoulos5,
  9. Mark Bolstridge2,
  10. Krish D. Singh1,
  11. Amanda Feilding6,
  12. Karl J. Friston3, and
  13. David J. Nutt2
  1. 1Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF119BJ, United Kingdom,
  2. 2Imperial College London, Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, London W12 ONN, United Kingdom,
  3. 3Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom,
  4. 4Sir Peter Mansfield Magnetic Resonance Centre, Nottingham University, Nottingham NG7 2RD, United Kingdom,
  5. 5Academic Unit of Psychiatry, University of Bristol, Bristol BS8 2BN, United Kingdom,
  6. 6The Beckley Foundation, Beckley Park, Oxford OX3 9SY, United Kingdom, and
  7. 7Virginia Tech Carilion Research Institute, and Bradley Department of Electrical & Computer Engineering, Virginia Polytechnic Institute and State University, Roanoke, Virginia 24016
View Full Text

Author contributions

  1. Author contributions: S.D.M., R.L.C.-H., A.F., and D.J.N. designed research; S.D.M., R.L.C.-H., T.M.W., D.E., B.S., A.P., and M.B. performed research; S.D.M., R.J.M., M.J.B., K.D.S., and K.J.F. contributed unpublished reagents/analytic tools; S.D.M. and R.L.C.-H. analyzed data; S.D.M., R.L.C.-H., R.J.M., M.J.B., K.J.F., and D.J.N. wrote the paper.

  2. ↵*S.D.M. and R.L.C.-H. contributed equally to this work.

Disclosures

    • Received May 13, 2013.
    • Revision received August 5, 2013.
    • Accepted August 8, 2013.
  • This research received financial and intellectual support from the Beckley Foundation and was conducted as part of the Beckley-Imperial Psychedelic Research Programme. The authors thank Alison Diaper and the research volunteers.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Robin L. Carhart-Harris, Imperial College London, Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, London W12 ONN, United Kingdom. r.carhart-harris{at}imperial.ac.uk

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Jan 20188718553
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May 202189291137
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Jul 202411213752
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Total 2024138630311039
Jan 20258516484
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Mar 20258520279
Apr 20258422492
May 202511725494
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Total 20255041346482
Total7498215166745
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The Journal of Neuroscience: 33 (38)
Journal of Neuroscience
Vol. 33, Issue 38
18 Sep 2013
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Broadband Cortical Desynchronization Underlies the Human Psychedelic State
Suresh D. Muthukumaraswamy, Robin L. Carhart-Harris, Rosalyn J. Moran, Matthew J. Brookes, Tim M. Williams, David Errtizoe, Ben Sessa, Andreas Papadopoulos, Mark Bolstridge, Krish D. Singh, Amanda Feilding, Karl J. Friston, David J. Nutt
Journal of Neuroscience 18 September 2013, 33 (38) 15171-15183; DOI: 10.1523/JNEUROSCI.2063-13.2013

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Broadband Cortical Desynchronization Underlies the Human Psychedelic State
Suresh D. Muthukumaraswamy, Robin L. Carhart-Harris, Rosalyn J. Moran, Matthew J. Brookes, Tim M. Williams, David Errtizoe, Ben Sessa, Andreas Papadopoulos, Mark Bolstridge, Krish D. Singh, Amanda Feilding, Karl J. Friston, David J. Nutt
Journal of Neuroscience 18 September 2013, 33 (38) 15171-15183; DOI: 10.1523/JNEUROSCI.2063-13.2013
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