Article Figures & Data
Figures
- Figure 1.
Adaptation in PrV and SpVi example cells. A, Average membrane potential of a PrV neuron recorded at a depth of 3615 μm (resting potential, −60.6 mV). The PW was stimulated 20 times at 18 Hz (black bars), at either high (red) or low (blue) intensity. B, Average peak PSPs in A normalized to the first PSP (high, red circles; low, blue squares). Each data point was calculated by measuring the peak PSPs in individual trials followed by averaging. The response to high-intensity stimulation adapts less despite the larger response to the first stimulus. C, Separation of the two nuclei. D, E, Examples of histological labeling made using broken sharp electrodes coated with DiI to the PrV (D) and SpVi (E). F, G, Same as A and B for an SpVi neuron recorded at a depth of 2436 μm (resting potential, −52.5 mV). The response to high-intensity stimulation adapts more.
- Figure 2.
Adaptation patterns in PrV and SpVi are inversely dependent on tactile intensity. A, Penetration depth and adaptation type of all intracellularly recorded neurons. Type II, Cells demonstrating less adaption with increasing intensity of stimulation; type I, cells demonstrating more adaption with increasing intensity of stimulation. B, Average response of 18 PrV neurons. Peak PSPs were normalized to the peak of the first response for each cell before the data were pulled and averaged across the population. Response to high-intensity stimulation adapted significantly less in comparison with the lower-intensity stimulation. C, Fifteen SpVi neurons: responses to the low-intensity stimulation adapted significantly less compared with the higher-intensity stimulation. D, As in A for extracellularly recorded neurons. E, F, Spike data of 32 PrV neurons and 13 SpVi neurons: spike counts per stimulation were normalized for each cell to the first response.
- Figure 3.
Intensity-dependent adaptation to AW stimulation of PrV neurons. A, The average normalized response of a subset of cells (n = 12) to high- and low-intensity stimulation of the PW. The response to high-intensity stimulation adapted significantly less than low-intensity stimulation. B, The average normalized responses of the same set of cells to identical AW deflections. The response to low-intensity stimulation adapted significantly less than high-intensity stimulation. C, PSP probability analysis for the responses in A. The probability of observing a PSP to low-intensity stimulation adapted significantly more than that for the high-intensity stimulation. D, PSP probability analysis for the stimulated AWs of the same set of PrV neurons showed more adaptation for the high-intensity stimulation than for the low-intensity stimulation.
