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Articles, Systems/Circuits

Amygdala β-Noradrenergic Receptors Modulate Delayed Downregulation of Dopamine Activity following Restraint

Chun-hui Chang and Anthony A. Grace
Journal of Neuroscience 23 January 2013, 33 (4) 1441-1450; DOI: https://doi.org/10.1523/JNEUROSCI.2420-12.2013
Chun-hui Chang
Departments of Neuroscience, Psychology, and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
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Anthony A. Grace
Departments of Neuroscience, Psychology, and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
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Abstract

Stress, which involves a heightened arousal and excitability, triggers important adaptive responses to maintain homeostasis and prepare a response. In the current studies, we administered a psychological stressor of 2 h acute restraint on rats, and found that 24 h after the cessation of the restraint session, there was a significant decrease in ventral tegmental area dopaminergic (DA) neuron population activity and a significant attenuation in amphetamine-induced locomotor activity. Systemic or intra-basolateral nuclei of the amygdala administration of the β-noradrenergic receptor antagonist, propranolol, reversed the decrease, suggesting that the delayed attenuation of DA neuron firing following a stressor depends on a noradrenaline-mediated mechanism. This alteration in DA activity may adaptively prepare the individual to avoid the stressor, or in the extreme, may be a factor that contributes to pathological changes in behavior or physiological responses.

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The Journal of Neuroscience: 33 (4)
Journal of Neuroscience
Vol. 33, Issue 4
23 Jan 2013
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Amygdala β-Noradrenergic Receptors Modulate Delayed Downregulation of Dopamine Activity following Restraint
Chun-hui Chang, Anthony A. Grace
Journal of Neuroscience 23 January 2013, 33 (4) 1441-1450; DOI: 10.1523/JNEUROSCI.2420-12.2013

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Amygdala β-Noradrenergic Receptors Modulate Delayed Downregulation of Dopamine Activity following Restraint
Chun-hui Chang, Anthony A. Grace
Journal of Neuroscience 23 January 2013, 33 (4) 1441-1450; DOI: 10.1523/JNEUROSCI.2420-12.2013
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