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Articles, Cellular/Molecular

Peptide Inhibitors Disrupt the Serotonin 5-HT2C Receptor Interaction with Phosphatase and Tensin Homolog to Allosterically Modulate Cellular Signaling and Behavior

Noelle C. Anastasio, Scott R. Gilbertson, Marcy J. Bubar, Anton Agarkov, Sonja J. Stutz, Yowjiun Jeng, Nicole M. Bremer, Thressa D. Smith, Robert G. Fox, Sarah E. Swinford, Patricia K. Seitz, Marc N. Charendoff, John W. Craft Jr, Fernanda M. Laezza, Cheryl S. Watson, James M. Briggs and Kathryn A. Cunningham
Journal of Neuroscience 23 January 2013, 33 (4) 1615-1630; DOI: https://doi.org/10.1523/JNEUROSCI.2656-12.2013
Noelle C. Anastasio
1Center for Addiction Research and
2Departments of Pharmacology and Toxicology and
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Scott R. Gilbertson
1Center for Addiction Research and
4Departments of Chemistry and
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Marcy J. Bubar
1Center for Addiction Research and
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Anton Agarkov
4Departments of Chemistry and
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Sonja J. Stutz
1Center for Addiction Research and
2Departments of Pharmacology and Toxicology and
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Yowjiun Jeng
1Center for Addiction Research and
2Departments of Pharmacology and Toxicology and
3Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, and
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Nicole M. Bremer
1Center for Addiction Research and
2Departments of Pharmacology and Toxicology and
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Thressa D. Smith
1Center for Addiction Research and
2Departments of Pharmacology and Toxicology and
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Robert G. Fox
1Center for Addiction Research and
2Departments of Pharmacology and Toxicology and
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Sarah E. Swinford
1Center for Addiction Research and
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Patricia K. Seitz
1Center for Addiction Research and
2Departments of Pharmacology and Toxicology and
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Marc N. Charendoff
5Biology and Biochemistry, University of Houston, Houston, Texas 77004
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John W. Craft Jr
5Biology and Biochemistry, University of Houston, Houston, Texas 77004
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Fernanda M. Laezza
1Center for Addiction Research and
2Departments of Pharmacology and Toxicology and
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Cheryl S. Watson
1Center for Addiction Research and
3Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, and
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James M. Briggs
5Biology and Biochemistry, University of Houston, Houston, Texas 77004
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Kathryn A. Cunningham
1Center for Addiction Research and
2Departments of Pharmacology and Toxicology and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2656-12.2013
PubMed 
23345234
Published By 
Society for Neuroscience
History 
  • Received June 2, 2012
  • Revision received October 10, 2012
  • Accepted November 16, 2012
  • First published January 23, 2013.
  • Version of record published January 23, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/331615-16$15.00/0

Author Information

  1. Noelle C. Anastasio1,2,
  2. Scott R. Gilbertson1,4,
  3. Marcy J. Bubar1,
  4. Anton Agarkov4,
  5. Sonja J. Stutz1,2,
  6. Yowjiun Jeng1,2,3,
  7. Nicole M. Bremer1,2,
  8. Thressa D. Smith1,2,
  9. Robert G. Fox1,2,
  10. Sarah E. Swinford1,
  11. Patricia K. Seitz1,2,
  12. Marc N. Charendoff5,
  13. John W. Craft Jr5,
  14. Fernanda M. Laezza1,2,
  15. Cheryl S. Watson1,3,
  16. James M. Briggs5, and
  17. Kathryn A. Cunningham1,2
  1. 1Center for Addiction Research and
  2. 2Departments of Pharmacology and Toxicology and
  3. 3Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, and
  4. 4Departments of Chemistry and
  5. 5Biology and Biochemistry, University of Houston, Houston, Texas 77004
View Full Text

Author contributions

  1. Author contributions: N.C.A., S.R.G., M.J.B., C.S.W., J.M.B., and K.A.C. designed research; N.C.A., S.R.G., A.A., S.J.S., Y.J., N.M.B., T.D.S., R.G.F., S.E.S., P.K.S., M.N.C., J.W.C., and K.A.C. performed research; N.C.A., S.R.G., A.A., S.J.S., Y.J., N.M.B., T.D.S., R.G.F., S.E.S., P.K.S., M.N.C., J.W.C., F.M.L., C.S.W., J.M.B., and K.A.C. analyzed data; N.C.A., S.R.G., M.J.B., M.N.C., J.W.C., J.M.B., and K.A.C. wrote the paper.

Disclosures

    • Received June 2, 2012.
    • Revision received October 10, 2012.
    • Accepted November 16, 2012.
  • This work was supported by the Klarman Family Foundation, the Foundation for Prader-Willi Research, and National Institute of Drug Abuse Grants DA06511, DA024157, and DA020087. K.A.C. is an editor of Neuropsychopharmacology Reviews and receives compensation for this role from the American College of Neuropsychopharmacology. We thank Drs. Kelly Berg and William Clarke from the University of Texas Health Science Center at San Antonio for the gift of the CHO cell lines. We thank Dr. Adriana Paulucci-Holthauzen and Leoncio Vergara with the University of Texas Medical Branch Optical Microscopy Core for capturing confocal microscopy images and contributing to analysis of confocal photomicrographs. The NAMD (Not Another Molecular Dynamics) program was developed by the Theoretical and Computational Biophysics Group in the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign.

  • Correspondence should be addressed to Dr. Kathryn A. Cunningham, University of Texas Medical Branch Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555-0615. kcunning{at}utmb.edu

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Jan 201813304
Feb 2018152817
Mar 2018114511
Apr 201820373
May 2018144111
Jun 2018183912
Jul 201811473
Aug 201810616
Sep 201812605
Oct 201819323
Nov 201818216
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Jan 201912206
Feb 201915152
Mar 201923199
Apr 2019212710
May 2019262218
Jun 2019122013
Jul 201917218
Aug 201924766
Oct 2019371488
Nov 20196357
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Feb 20208209
Mar 202071210
May 202081812
Jun 20201227
Jul 20204163
Aug 20200166
Sep 202032820
Oct 202075116
Nov 20203296
Dec 20205309
Total 202059266103
Jan 202163017
Feb 202133210
Mar 2021104622
Apr 20216257
May 20213279
Jun 20213265
Jul 202142414
Aug 20214335
Sep 20215248
Oct 202104323
Nov 202122223
Dec 20214339
Total 202150365152
Jan 20223299
Feb 20223296
Mar 20221203
Apr 202212614
May 202263917
Jun 202233119
Jul 202232816
Aug 20222309
Sep 20223507
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Dec 2022182
Total 202232373114
Jan 202323511
Feb 202332720
Mar 202313411
Apr 20237367
May 20234317
Jun 202316351
Jul 2023243213
Aug 202327275
Sep 20231276
Total 20238528481
Total6002178631
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The Journal of Neuroscience: 33 (4)
Journal of Neuroscience
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23 Jan 2013
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Peptide Inhibitors Disrupt the Serotonin 5-HT2C Receptor Interaction with Phosphatase and Tensin Homolog to Allosterically Modulate Cellular Signaling and Behavior
Noelle C. Anastasio, Scott R. Gilbertson, Marcy J. Bubar, Anton Agarkov, Sonja J. Stutz, Yowjiun Jeng, Nicole M. Bremer, Thressa D. Smith, Robert G. Fox, Sarah E. Swinford, Patricia K. Seitz, Marc N. Charendoff, John W. Craft Jr, Fernanda M. Laezza, Cheryl S. Watson, James M. Briggs, Kathryn A. Cunningham
Journal of Neuroscience 23 January 2013, 33 (4) 1615-1630; DOI: 10.1523/JNEUROSCI.2656-12.2013

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Peptide Inhibitors Disrupt the Serotonin 5-HT2C Receptor Interaction with Phosphatase and Tensin Homolog to Allosterically Modulate Cellular Signaling and Behavior
Noelle C. Anastasio, Scott R. Gilbertson, Marcy J. Bubar, Anton Agarkov, Sonja J. Stutz, Yowjiun Jeng, Nicole M. Bremer, Thressa D. Smith, Robert G. Fox, Sarah E. Swinford, Patricia K. Seitz, Marc N. Charendoff, John W. Craft Jr, Fernanda M. Laezza, Cheryl S. Watson, James M. Briggs, Kathryn A. Cunningham
Journal of Neuroscience 23 January 2013, 33 (4) 1615-1630; DOI: 10.1523/JNEUROSCI.2656-12.2013
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