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Featured ArticleArticles, Cellular/Molecular

TASK-2 Channels Contribute to pH Sensitivity of Retrotrapezoid Nucleus Chemoreceptor Neurons

Sheng Wang, Najate Benamer, Sébastien Zanella, Natasha N. Kumar, Yingtang Shi, Michelle Bévengut, David Penton, Patrice G. Guyenet, Florian Lesage, Christian Gestreau, Jacques Barhanin and Douglas A. Bayliss
Journal of Neuroscience 9 October 2013, 33 (41) 16033-16044; https://doi.org/10.1523/JNEUROSCI.2451-13.2013
Sheng Wang
1Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908,
2Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei, 050017, China,
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Najate Benamer
3Université de Nice-Sophia Antipolis, Centre National de la Recherche Scientifique (CNRS), Laboratoire de PhysioMédecine Moléculaire (LP2M), Formation de Recherche en Evolution (FRE) 3472, Unité de Formation et de Recherche (UFR) Sciences, Parc Valrose, 06108 Nice, France,
6Laboratories of Excellence, Ion Channel Science and Therapeutics, France
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Sébastien Zanella
4Aix-Marseille-Université, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille–Unité Mixte de Recherche (UMR) 7286, 13344 Marseille, France,
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Natasha N. Kumar
1Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908,
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Yingtang Shi
1Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908,
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Michelle Bévengut
4Aix-Marseille-Université, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille–Unité Mixte de Recherche (UMR) 7286, 13344 Marseille, France,
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David Penton
3Université de Nice-Sophia Antipolis, Centre National de la Recherche Scientifique (CNRS), Laboratoire de PhysioMédecine Moléculaire (LP2M), Formation de Recherche en Evolution (FRE) 3472, Unité de Formation et de Recherche (UFR) Sciences, Parc Valrose, 06108 Nice, France,
6Laboratories of Excellence, Ion Channel Science and Therapeutics, France
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Patrice G. Guyenet
1Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908,
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Florian Lesage
5Université de Nice-Sophia Antipolis, CNRS, Institut de Pharmacologie Moléculaire, UMR7275, Sophia Antipolis, 06560 Valbonne, France, and
6Laboratories of Excellence, Ion Channel Science and Therapeutics, France
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Christian Gestreau
4Aix-Marseille-Université, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille–Unité Mixte de Recherche (UMR) 7286, 13344 Marseille, France,
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Jacques Barhanin
3Université de Nice-Sophia Antipolis, Centre National de la Recherche Scientifique (CNRS), Laboratoire de PhysioMédecine Moléculaire (LP2M), Formation de Recherche en Evolution (FRE) 3472, Unité de Formation et de Recherche (UFR) Sciences, Parc Valrose, 06108 Nice, France,
6Laboratories of Excellence, Ion Channel Science and Therapeutics, France
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Douglas A. Bayliss
1Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2451-13.2013
PubMed 
24107938
Published By 
Society for Neuroscience
History 
  • Received June 9, 2013
  • Revision received July 26, 2013
  • Accepted August 5, 2013
  • First published October 9, 2013.
  • Version of record published October 9, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/3316033-12$15.00/0 This article is freely available online through the J Neurosci Author Open Choice option.

Author Information

  1. Sheng Wang1,2,*,
  2. Najate Benamer3,6,*,
  3. Sébastien Zanella4,*,
  4. Natasha N. Kumar1,
  5. Yingtang Shi1,
  6. Michelle Bévengut4,
  7. David Penton3,6,
  8. Patrice G. Guyenet1,
  9. Florian Lesage5,6,
  10. Christian Gestreau4,†,
  11. Jacques Barhanin3,6,†, and
  12. Douglas A. Bayliss1,†
  1. 1Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908,
  2. 2Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei, 050017, China,
  3. 3Université de Nice-Sophia Antipolis, Centre National de la Recherche Scientifique (CNRS), Laboratoire de PhysioMédecine Moléculaire (LP2M), Formation de Recherche en Evolution (FRE) 3472, Unité de Formation et de Recherche (UFR) Sciences, Parc Valrose, 06108 Nice, France,
  4. 4Aix-Marseille-Université, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille–Unité Mixte de Recherche (UMR) 7286, 13344 Marseille, France,
  5. 5Université de Nice-Sophia Antipolis, CNRS, Institut de Pharmacologie Moléculaire, UMR7275, Sophia Antipolis, 06560 Valbonne, France, and
  6. 6Laboratories of Excellence, Ion Channel Science and Therapeutics, France
View Full Text

Author contributions

  1. Author contributions: S.W., S.Z., N.N.K., Y.S., P.G.G., C.G., J.B., and D.A.B. designed research; S.W., N.B., S.Z., N.N.K., Y.S., and D.P. performed research; F.L. contributed unpublished reagents/analytic tools; S.W., N.B., S.Z., N.N.K., Y.S., M.B., P.G.G., F.L., C.G., J.B., and D.A.B. analyzed data; S.Z., N.N.K., P.G.G., C.G., J.B., and D.A.B. wrote the paper.

  2. ↵*S.W., N.B., and S.Z. contributed equally to this work.

  3. ↵†C.G., J.B., and D.A.B. contributed equally to this work.

Disclosures

    • Received June 9, 2013.
    • Revision received July 26, 2013.
    • Accepted August 5, 2013.
  • This work was supported by National Institutes of Health Grants HL74011 (P.G.G.) and HL108609 (D.A.B.) and French National Agency for Research Grants ANR RESPITASK (J.B., C.G.) and ANR-11-LABX-0015-01 (J.B., .F.L.).

  • Correspondence should be addressed to one of the following: Christian Gestreau, Aix Marseille Université, CNRS, CRN2M-UMR7286, 13344 Marseille Cedex 15, Marseille, France, christian.gestreau{at}univ-amu.fr; Jacques Barhanin, Université de Nice-Sophia Antipolis, CNRS, Laboratoire de PhysioMédecine Moléculaire (LP2M), FRE 3472, UFR Sciences, Parc Valrose, 06108 Nice Cedex, France, jacques.barhanin{at}unice.fr; or Douglas A. Bayliss, Department of Pharmacology, 1340 Jefferson Park Avenue, University of Virginia School of Medicine, Charlottesville, VA 22908, bayliss{at}virginia.edu

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The Journal of Neuroscience: 33 (41)
Journal of Neuroscience
Vol. 33, Issue 41
9 Oct 2013
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TASK-2 Channels Contribute to pH Sensitivity of Retrotrapezoid Nucleus Chemoreceptor Neurons
Sheng Wang, Najate Benamer, Sébastien Zanella, Natasha N. Kumar, Yingtang Shi, Michelle Bévengut, David Penton, Patrice G. Guyenet, Florian Lesage, Christian Gestreau, Jacques Barhanin, Douglas A. Bayliss
Journal of Neuroscience 9 October 2013, 33 (41) 16033-16044; DOI: 10.1523/JNEUROSCI.2451-13.2013

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TASK-2 Channels Contribute to pH Sensitivity of Retrotrapezoid Nucleus Chemoreceptor Neurons
Sheng Wang, Najate Benamer, Sébastien Zanella, Natasha N. Kumar, Yingtang Shi, Michelle Bévengut, David Penton, Patrice G. Guyenet, Florian Lesage, Christian Gestreau, Jacques Barhanin, Douglas A. Bayliss
Journal of Neuroscience 9 October 2013, 33 (41) 16033-16044; DOI: 10.1523/JNEUROSCI.2451-13.2013
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