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Cover ArticleArticles, Systems/Circuits

Distinct Parietal and Temporal Connectivity Profiles of Ventrolateral Frontal Areas Involved in Language Production

Daniel S. Margulies and Michael Petrides
Journal of Neuroscience 16 October 2013, 33 (42) 16846-16852; https://doi.org/10.1523/JNEUROSCI.2259-13.2013
Daniel S. Margulies
1Max Planck Research Group: Neuroanatomy & Connectivity, Max Planck Institute for Human Cognitive and Brain Sciences, 04103, Leipzig, Germany, and
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Michael Petrides
2Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
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    Figure 1.

    a, Schematic diagram of the architectonic areas of interest along the ventrolateral frontal and inferior parietal cortex in the macaque monkey with anatomical connections indicated (b). Note that adjacent areas are always interconnected. R, Rostral; VR, ventrorostral; VC, ventrocaudal; DC, dorsocaudal; d, dorsal; v, ventral; a, anterior; p, posterior; STS, superior temporal sulcus; ProM, proisocortical motor area.

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    Figure 2.

    a, Color-coded schematic of the rostrocaudal arrangement of the ventrolateral and inferior parietal cortical areas of interest. Below is a schematic of the morphology of the ROI, with location of seed regions and anatomical labels: vr, vertical ramus; hr, horizontal ramus; cs, central sulcus; ds, diagonal sulcus; PrG, precentral gyrus; half, horizontal anterior limb of the Sylvian fissure; IFG, inferior frontal gyrus; ifs, inferior frontal sulcus; iprs, inferior precentral; Op, pars opercularis; Tr, pars triangularis; ts, triangular sulcus. b, Group level; peak shown as white dots on the inflated right (RH) and left (LH) hemisphere connectivity maps. c, Individual-level functional connectivity results from six individuals, color coded as in a. Note that, in all cases, there was connectivity with the corresponding homotopic area in the contralateral hemisphere.

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    Figure 3.

    Summary diagram of the connectivity profiles of the ventrolateral frontal areas of interest. Terms in gray refer to cortical lobes, and terms in black refer to specific cortical areas: STS, superior temporal sulcus; PMCm, middle posteromedial cortex; a, anterior; m, middle; p, posterior.

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The Journal of Neuroscience: 33 (42)
Journal of Neuroscience
Vol. 33, Issue 42
16 Oct 2013
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Distinct Parietal and Temporal Connectivity Profiles of Ventrolateral Frontal Areas Involved in Language Production
Daniel S. Margulies, Michael Petrides
Journal of Neuroscience 16 October 2013, 33 (42) 16846-16852; DOI: 10.1523/JNEUROSCI.2259-13.2013

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Distinct Parietal and Temporal Connectivity Profiles of Ventrolateral Frontal Areas Involved in Language Production
Daniel S. Margulies, Michael Petrides
Journal of Neuroscience 16 October 2013, 33 (42) 16846-16852; DOI: 10.1523/JNEUROSCI.2259-13.2013
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