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Articles, Neurobiology of Disease

Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain

Jeffrey J. Iliff, Minghuan Wang, Douglas M. Zeppenfeld, Arun Venkataraman, Benjamin A. Plog, Yonghong Liao, Rashid Deane and Maiken Nedergaard
Journal of Neuroscience 13 November 2013, 33 (46) 18190-18199; https://doi.org/10.1523/JNEUROSCI.1592-13.2013
Jeffrey J. Iliff
1Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642,
2Department of Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, Portland, Oregon 97239, and
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Minghuan Wang
1Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642,
3Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030
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Douglas M. Zeppenfeld
1Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642,
2Department of Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, Portland, Oregon 97239, and
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Arun Venkataraman
1Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642,
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Benjamin A. Plog
1Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642,
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Yonghong Liao
1Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642,
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Rashid Deane
1Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642,
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Maiken Nedergaard
1Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1592-13.2013
PubMed 
24227727
Published By 
Society for Neuroscience
History 
  • Received April 15, 2013
  • Revision received October 4, 2013
  • Accepted October 12, 2013
  • First published November 13, 2013.
  • Version of record published November 13, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/3318190-10$15.00/0

Author Information

  1. Jeffrey J. Iliff1,2,
  2. Minghuan Wang1,3,
  3. Douglas M. Zeppenfeld1,2,
  4. Arun Venkataraman1,
  5. Benjamin A. Plog1,
  6. Yonghong Liao1,
  7. Rashid Deane1, and
  8. Maiken Nedergaard1
  1. 1Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642,
  2. 2Department of Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, Portland, Oregon 97239, and
  3. 3Department of Neurology, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, China 430030
View Full Text

Author contributions

  1. Author contributions: J.J.I., M.W., R.D., and M.N. designed research; J.J.I., M.W., D.M.Z., and Y.L. performed research; J.J.I., M.W., D.M.Z., A.V., and B.A.P. analyzed data; J.J.I. and M.N. wrote the paper.

Disclosures

    • Received April 15, 2013.
    • Revision received October 4, 2013.
    • Accepted October 12, 2013.
  • This work was supported by the National Institutes of Health (J.J.I., M.N.), the United States Department of Defense (M.N.), the Harold and Leila Y. Mathers Charitable Foundation (M.N.), and the American Heart Association (J.J.I.).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Jeffrey J. Iliff, PhD, Department of Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Mail Code HRC5N, Portland, OR 97239. iliffj{at}ohsu.edu

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Jan 201896147
Feb 20181323635
Mar 201849637
Apr 2018913338
May 201898125
Jun 20181210431
Jul 2018155520
Aug 201875827
Sep 2018146452
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Nov 2018127137
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Total 20181401091435
Jan 2019147646
Feb 2019267437
Mar 2019167871
Apr 2019375766
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Jun 2019217449
Jul 201985442
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Oct 20191318239
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Total 2019196959567
Jan 2020199036
Feb 2020128641
Mar 2020106438
May 20201510151
Jun 2020176532
Jul 2020166838
Aug 2020118463
Sep 2020318450
Oct 2020168549
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Total 2020217959529
Jan 2021179674
Feb 20212212169
Mar 202130121100
Apr 2021199160
May 20212310868
Jun 20211910565
Jul 20212110276
Aug 2021149954
Sep 20211810881
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Total 20212651392964
Jan 20221811183
Feb 20222611576
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May 20222110972
Jun 20221413170
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Total 20222371341742
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Apr 20231311581
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Jun 20232513673
Jul 20234613698
Aug 20232616072
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Total 202339826681006
Jan 202448163115
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Apr 202425322105
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Jun 20241215481
Jul 202432181101
Aug 20244118682
Sep 202446227102
Oct 202471315101
Nov 202440224120
Dec 202450260111
Total 202447928541247
Jan 202549283146
Feb 202561376168
Mar 202535320105
Apr 20252634287
May 20254928795
Jun 20252221686
Jul 202568025
Total 20252481904712
Total2180131686202
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The Journal of Neuroscience: 33 (46)
Journal of Neuroscience
Vol. 33, Issue 46
13 Nov 2013
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Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain
Jeffrey J. Iliff, Minghuan Wang, Douglas M. Zeppenfeld, Arun Venkataraman, Benjamin A. Plog, Yonghong Liao, Rashid Deane, Maiken Nedergaard
Journal of Neuroscience 13 November 2013, 33 (46) 18190-18199; DOI: 10.1523/JNEUROSCI.1592-13.2013

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Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain
Jeffrey J. Iliff, Minghuan Wang, Douglas M. Zeppenfeld, Arun Venkataraman, Benjamin A. Plog, Yonghong Liao, Rashid Deane, Maiken Nedergaard
Journal of Neuroscience 13 November 2013, 33 (46) 18190-18199; DOI: 10.1523/JNEUROSCI.1592-13.2013
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