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Featured ArticleArticles, Systems/Circuits

Neuroestradiol in the Hypothalamus Contributes to the Regulation of Gonadotropin Releasing Hormone Release

Brian P. Kenealy, Amita Kapoor, Kathryn A. Guerriero, Kim L. Keen, James P. Garcia, Joseph R. Kurian, Toni E. Ziegler and Ei Terasawa
Journal of Neuroscience 4 December 2013, 33 (49) 19051-19059; DOI: https://doi.org/10.1523/JNEUROSCI.3878-13.2013
Brian P. Kenealy
1Wisconsin National Primate Research Center, and
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Amita Kapoor
1Wisconsin National Primate Research Center, and
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Kathryn A. Guerriero
1Wisconsin National Primate Research Center, and
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Kim L. Keen
1Wisconsin National Primate Research Center, and
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James P. Garcia
1Wisconsin National Primate Research Center, and
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Joseph R. Kurian
1Wisconsin National Primate Research Center, and
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Toni E. Ziegler
1Wisconsin National Primate Research Center, and
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Ei Terasawa
1Wisconsin National Primate Research Center, and
2Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53715
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Abstract

Release of gonadotropin releasing hormone (GnRH) from the medial basal hypothalamus (MBH)/median eminence region (S-ME) is essential for normal reproductive function. GnRH release is profoundly regulated by the negative and positive feedback effects of ovarian estradiol (E2). Here we report that neuroestradiol, released in the S-ME, also directly influences GnRH release in ovariectomized female monkeys, in which the ovarian source of E2 is removed. We found that (1) brief infusion of E2 benzoate (EB) to the S-ME rapidly stimulated release of GnRH and E2 in the S-ME of ovariectomized monkeys, (2) electrical stimulation of the MBH resulted in GnRH release as well as E2 release, and (3) direct infusion of an aromatase inhibitor to the S-ME suppressed spontaneous GnRH release as well as the EB-induced release of GnRH and E2. These findings reveal the importance of neuroestradiol as a neurotransmitter in regulation of GnRH release. How circulating ovarian E2 interacts with hypothalamic neuroestrogens in the control of GnRH release remains to be investigated.

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The Journal of Neuroscience: 33 (49)
Journal of Neuroscience
Vol. 33, Issue 49
4 Dec 2013
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Neuroestradiol in the Hypothalamus Contributes to the Regulation of Gonadotropin Releasing Hormone Release
Brian P. Kenealy, Amita Kapoor, Kathryn A. Guerriero, Kim L. Keen, James P. Garcia, Joseph R. Kurian, Toni E. Ziegler, Ei Terasawa
Journal of Neuroscience 4 December 2013, 33 (49) 19051-19059; DOI: 10.1523/JNEUROSCI.3878-13.2013

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Neuroestradiol in the Hypothalamus Contributes to the Regulation of Gonadotropin Releasing Hormone Release
Brian P. Kenealy, Amita Kapoor, Kathryn A. Guerriero, Kim L. Keen, James P. Garcia, Joseph R. Kurian, Toni E. Ziegler, Ei Terasawa
Journal of Neuroscience 4 December 2013, 33 (49) 19051-19059; DOI: 10.1523/JNEUROSCI.3878-13.2013
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