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Articles, Behavioral/Cognitive

Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression

Eric J. Nunes, Patrick A. Randall, Evan E. Hart, Charlotte Freeland, Samantha E. Yohn, Younis Baqi, Christa E. Müller, Laura López-Cruz, Mercè Correa and John D. Salamone
Journal of Neuroscience 4 December 2013, 33 (49) 19120-19130; https://doi.org/10.1523/JNEUROSCI.2730-13.2013
Eric J. Nunes
1Department of Psychology, University of Connecticut, Storrs, Connecticut 06269-1020,
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Patrick A. Randall
1Department of Psychology, University of Connecticut, Storrs, Connecticut 06269-1020,
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Evan E. Hart
1Department of Psychology, University of Connecticut, Storrs, Connecticut 06269-1020,
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Charlotte Freeland
1Department of Psychology, University of Connecticut, Storrs, Connecticut 06269-1020,
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Samantha E. Yohn
1Department of Psychology, University of Connecticut, Storrs, Connecticut 06269-1020,
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Younis Baqi
2Universität Bonn, Pharma-Zentrum Bonn, Pharmazeutisches Institut, Pharmazeutische Chemie, 53121 Bonn, Germany, and
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Christa E. Müller
2Universität Bonn, Pharma-Zentrum Bonn, Pharmazeutisches Institut, Pharmazeutische Chemie, 53121 Bonn, Germany, and
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Laura López-Cruz
3Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain
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Mercè Correa
1Department of Psychology, University of Connecticut, Storrs, Connecticut 06269-1020,
3Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain
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John D. Salamone
1Department of Psychology, University of Connecticut, Storrs, Connecticut 06269-1020,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2730-13.2013
PubMed 
24305809
Published By 
Society for Neuroscience
History 
  • Received June 27, 2013
  • Revision received October 11, 2013
  • Accepted October 15, 2013
  • First published December 4, 2013.
  • Version of record published December 4, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/3319120-11$15.00/0

Author Information

  1. Eric J. Nunes1,
  2. Patrick A. Randall1,
  3. Evan E. Hart1,
  4. Charlotte Freeland1,
  5. Samantha E. Yohn1,
  6. Younis Baqi2,
  7. Christa E. Müller2,
  8. Laura López-Cruz3,
  9. Mercè Correa1,3, and
  10. John D. Salamone1
  1. 1Department of Psychology, University of Connecticut, Storrs, Connecticut 06269-1020,
  2. 2Universität Bonn, Pharma-Zentrum Bonn, Pharmazeutisches Institut, Pharmazeutische Chemie, 53121 Bonn, Germany, and
  3. 3Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain
View Full Text

Author contributions

  1. Author contributions: E.N., P.R., M.C., and J.D.S. designed research; E.N., P.R., E.H., C.F., and S.E.Y. performed research; Y.B. and C.M. contributed unpublished reagents/analytic tools; E.N., P.R., E.H., C.F., L.L.C., M.C., and J.D.S. analyzed data; E.N., C.M., M.C., and J.D.S. wrote the paper.

Disclosures

    • Received June 27, 2013.
    • Revision received October 11, 2013.
    • Accepted October 15, 2013.
  • This work was supported by the National Institutes of Health–National Institute of Mental Health (Grant MH094966 to J.D.S.), Fundació Bancaixa/U. Jaume I. (Grant P1.1B2010–43 to M.C.), and a Student Undergraduate Research Fellowship grant to C.F. We thank Matthew Eastman and Joanne Conover for their help with the microscopy.

  • J.D.S. has received grants from Merck-Serrono, Pfizer, and Roche and is a consultant for Merz. The remaining authors declare no competing financial interests.

  • Correspondence should be addressed to John D. Salamone, PhD, Board of Trustees Distinguished Professor, Head, Division of Behavioral Neuroscience, Dept. of Psychology, University of Connecticut, Storrs, CT 06269-1020. john.salamone{at}uconn.edu

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Total 20254030699
Total103343021294
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The Journal of Neuroscience: 33 (49)
Journal of Neuroscience
Vol. 33, Issue 49
4 Dec 2013
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Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression
Eric J. Nunes, Patrick A. Randall, Evan E. Hart, Charlotte Freeland, Samantha E. Yohn, Younis Baqi, Christa E. Müller, Laura López-Cruz, Mercè Correa, John D. Salamone
Journal of Neuroscience 4 December 2013, 33 (49) 19120-19130; DOI: 10.1523/JNEUROSCI.2730-13.2013

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Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression
Eric J. Nunes, Patrick A. Randall, Evan E. Hart, Charlotte Freeland, Samantha E. Yohn, Younis Baqi, Christa E. Müller, Laura López-Cruz, Mercè Correa, John D. Salamone
Journal of Neuroscience 4 December 2013, 33 (49) 19120-19130; DOI: 10.1523/JNEUROSCI.2730-13.2013
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Keywords

  • decision making
  • vigor
  • motivation
  • negative symptoms
  • basal ganglia
  • DAT inhibitor

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