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Brief Communications

Acid-Sensing Ion Channel-1a Is Not Required for Normal Hippocampal LTP and Spatial Memory

Pu-Yeh Wu, Yu-Yin Huang, Chien-Chun Chen, Tsan-Ting Hsu, Yen-Chu Lin, Ju-Yun Weng, Ta-Chun Chien, Irene H Cheng and Cheng-Chang Lien
Journal of Neuroscience 30 January 2013, 33 (5) 1828-1832; https://doi.org/10.1523/JNEUROSCI.4132-12.2013
Pu-Yeh Wu
1Institute of Neuroscience,
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Yu-Yin Huang
2Institute of Clinical Medicine,
5Department of Anesthesiology, Cheng Hsin General Hospital, Taipei 112, Taiwan,
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Chien-Chun Chen
1Institute of Neuroscience,
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Tsan-Ting Hsu
1Institute of Neuroscience,
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Yen-Chu Lin
1Institute of Neuroscience,
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Ju-Yun Weng
1Institute of Neuroscience,
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Ta-Chun Chien
6Institute of Biochemistry and Molecular Biology, School of Life Sciences, National Yang-Ming University, Taipei 112, Taiwan, and
7Molecular Medicine Program, Taiwan International Graduate Program, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
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Irene H Cheng
3Institute of Brain Science,
4Brain Research Center, National Yang-Ming University, Taipei 112, Taiwan,
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Cheng-Chang Lien
1Institute of Neuroscience,
4Brain Research Center, National Yang-Ming University, Taipei 112, Taiwan,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4132-12.2013
PubMed 
23365222
Published By 
Society for Neuroscience
History 
  • Received August 28, 2012
  • Revision received November 11, 2012
  • Accepted November 16, 2012
  • First published January 30, 2013.
  • Version of record published January 30, 2013.
Copyright & Usage 
Copyright © 2013 the authors 0270-6474/13/331828-05$15.00/0

Author Information

  1. Pu-Yeh Wu1,*,
  2. Yu-Yin Huang2,5,*,
  3. Chien-Chun Chen1,*,
  4. Tsan-Ting Hsu1,*,
  5. Yen-Chu Lin1,
  6. Ju-Yun Weng1,
  7. Ta-Chun Chien6,7,
  8. Irene H Cheng3,4, and
  9. Cheng-Chang Lien1,4
  1. 1Institute of Neuroscience,
  2. 2Institute of Clinical Medicine,
  3. 3Institute of Brain Science,
  4. 4Brain Research Center, National Yang-Ming University, Taipei 112, Taiwan,
  5. 5Department of Anesthesiology, Cheng Hsin General Hospital, Taipei 112, Taiwan,
  6. 6Institute of Biochemistry and Molecular Biology, School of Life Sciences, National Yang-Ming University, Taipei 112, Taiwan, and
  7. 7Molecular Medicine Program, Taiwan International Graduate Program, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
View Full Text

Author contributions

  1. Author contributions: P.-Y.W., Y.-Y.H., C.-C.C., I.H.C., and C.-C.L. designed research; P.-Y.W., Y.-Y.H., C.-C.C., T.-T.H., Y.-C.L., J.-Y.W., and T.-C.C. performed research; P.-Y.W. and C.-C.C. analyzed data; C.-C.L. wrote the paper.

  2. ↵*P.-Y.W., Y.-Y.H., C.-C.C., and T.-T. H. contributed equally to this work.

Disclosures

    • Received August 28, 2012.
    • Revision received November 11, 2012.
    • Accepted November 16, 2012.
  • This work was supported by grants from the Ministry of Education, Aim for the Top University Plan, National Health Research Institutes (NHRI-EX100-9720NC), Taiwan National Science Council (NSC) (NSC 101-2321-B-010-024 and NSC 99-2321-B-010-001 to C.-C.L.; NSC 101-2320-B-010-069 to I.H.C.), and Cheng Hsin General Hospital (grant nos. 100-53 and 100F117CY19). We thank Dr. X. M. Chen for critically reading the manuscript; Drs. F. C. Liu and T. F. Tsai for providing the Tg(Nes-Cre) mice; Transgenic Mouse Model Core Facility of the National Core Facility Program for Biotechnology, NSC, and the Gene Knockout Mouse Core Laboratory of National Taiwan University Center of Genomic Medicine for generation of ASIC1a mutant mice; and the Animal Behavioral Core at Brain Research Center of National Yang-Ming University for behavioral studies.

  • Correspondence should be addressed to Cheng-Chang Lien, Institute of Neuroscience, National Yang-Ming University, 155, Section 2, Li-Nong Street, Taipei 112, Taiwan. cclien{at}ym.edu.tw

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The Journal of Neuroscience: 33 (5)
Journal of Neuroscience
Vol. 33, Issue 5
30 Jan 2013
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Acid-Sensing Ion Channel-1a Is Not Required for Normal Hippocampal LTP and Spatial Memory
Pu-Yeh Wu, Yu-Yin Huang, Chien-Chun Chen, Tsan-Ting Hsu, Yen-Chu Lin, Ju-Yun Weng, Ta-Chun Chien, Irene H Cheng, Cheng-Chang Lien
Journal of Neuroscience 30 January 2013, 33 (5) 1828-1832; DOI: 10.1523/JNEUROSCI.4132-12.2013

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Acid-Sensing Ion Channel-1a Is Not Required for Normal Hippocampal LTP and Spatial Memory
Pu-Yeh Wu, Yu-Yin Huang, Chien-Chun Chen, Tsan-Ting Hsu, Yen-Chu Lin, Ju-Yun Weng, Ta-Chun Chien, Irene H Cheng, Cheng-Chang Lien
Journal of Neuroscience 30 January 2013, 33 (5) 1828-1832; DOI: 10.1523/JNEUROSCI.4132-12.2013
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