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Articles, Behavioral/Cognitive

Internal and External Influences on the Rate of Sensory Evidence Accumulation in the Human Brain

Simon P. Kelly and Redmond G. O'Connell
Journal of Neuroscience 11 December 2013, 33 (50) 19434-19441; DOI: https://doi.org/10.1523/JNEUROSCI.3355-13.2013
Simon P. Kelly
1Department of Biomedical Engineering, City College of the City University of New York, New York, New York 10031, and
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Redmond G. O'Connell
2Trinity College Institute of Neuroscience and School of Psychology, Trinity College Dublin, Dublin 2, Ireland
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Abstract

We frequently need to make timely decisions based on sensory evidence that is weak, ambiguous, or noisy resulting from conditions in the external environment (e.g., a cluttered visual scene) or within the brain itself (e.g., inattention, neural noise). Here we examine how externally and internally driven variations in the quality of sensory evidence affect the build-to-threshold dynamics of a supramodal “decision variable” signal and, hence, the timing and accuracy of decision reports in humans. Observers performed a continuous-monitoring version of the prototypical two-alternative dot-motion discrimination task, which is known to strongly benefit from sequential sampling and temporal accumulation of evidence. A centroparietal positive potential (CPP), which we previously established as a supramodal decision signal based on its invariance to motor or sensory parameters, exhibited two key identifying properties associated with the “decision variable” long described in sequential sampling models: (1) its buildup rate systematically scaled with sensory evidence strength across four levels of motion coherence, consistent with temporal integration; and (2) its amplitude reached a stereotyped level at the moment of perceptual report executions, consistent with a boundary-crossing stopping criterion. The buildup rate of the CPP also strongly predicted reaction time within coherence levels (i.e., independent of physical evidence strength), and this endogenous variation was linked with attentional fluctuations indexed by the level of parieto-occipital α-band activity preceding target onset. In tandem with the CPP, build-to-threshold dynamics were also observed in an effector-selective motor preparation signal; however, the buildup of this motor-specific process significantly lagged that of the supramodal process.

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The Journal of Neuroscience: 33 (50)
Journal of Neuroscience
Vol. 33, Issue 50
11 Dec 2013
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Internal and External Influences on the Rate of Sensory Evidence Accumulation in the Human Brain
Simon P. Kelly, Redmond G. O'Connell
Journal of Neuroscience 11 December 2013, 33 (50) 19434-19441; DOI: 10.1523/JNEUROSCI.3355-13.2013

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Internal and External Influences on the Rate of Sensory Evidence Accumulation in the Human Brain
Simon P. Kelly, Redmond G. O'Connell
Journal of Neuroscience 11 December 2013, 33 (50) 19434-19441; DOI: 10.1523/JNEUROSCI.3355-13.2013
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