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Articles, Systems/Circuits

Cholinergic Blockade Reduces Theta-Gamma Phase Amplitude Coupling and Speed Modulation of Theta Frequency Consistent with Behavioral Effects on Encoding

Ehren L. Newman, Shea N. Gillet, Jason R. Climer and Michael E. Hasselmo
Journal of Neuroscience 11 December 2013, 33 (50) 19635-19646; DOI: https://doi.org/10.1523/JNEUROSCI.2586-13.2013
Ehren L. Newman
1Center for Memory and Brain, Department of Psychology, Boston University, Boston, Massachusetts 02215 and
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Shea N. Gillet
2Graduate Program, Division of Biological Sciences and Center for Neural Circuits and Behavior, Department of Neurosciences, University of California, San Diego, La Jolla, California 92093
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Jason R. Climer
1Center for Memory and Brain, Department of Psychology, Boston University, Boston, Massachusetts 02215 and
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Michael E. Hasselmo
1Center for Memory and Brain, Department of Psychology, Boston University, Boston, Massachusetts 02215 and
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Abstract

Large-scale neural activation dynamics in the hippocampal-entorhinal circuit local field potential, observable as theta and gamma rhythms and coupling between these rhythms, is predictive of encoding success. Behavioral studies show that systemic administration of muscarinic acetylcholine receptor antagonists selectively impairs encoding, suggesting that they may also disrupt the coupling between the theta and gamma bands. Here, we tested the hypothesis that muscarinic antagonists selectively disrupt coupling between theta and gamma. Specifically, we characterized the effects of systemically administered scopolamine on movement-induced theta and gamma rhythms recorded in the superficial layers of the medial entorhinal cortex (MEC) of freely moving rats. We report the novel result that gamma power at the peak of theta was most reduced following muscarinic blockade, significantly shifting the phase of maximal gamma power to occur at later phases of theta. We also characterize the existence of multiple distinct gamma bands in the superficial layers of the MEC. Further, we observed that theta frequency was significantly less modulated by movement speed following muscarinic blockade. Finally, the slope relating speed to theta frequency, a correlate of familiarity with a testing enclosure, increased significantly less between the preinjection and recovery trials when scopolamine was administered during the intervening injection session than when saline was administered, suggesting that scopolamine reduced encoding of the testing enclosure. These data are consistent with computational models suggesting that encoding and retrieval occur during the peak and trough of theta, respectively, and support the theory that acetylcholine regulates the balance between encoding versus retrieval.

  • theta
  • gamma
  • acetylcholine
  • entorhinal cortex
  • encoding
  • path integration
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The Journal of Neuroscience: 33 (50)
Journal of Neuroscience
Vol. 33, Issue 50
11 Dec 2013
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Cholinergic Blockade Reduces Theta-Gamma Phase Amplitude Coupling and Speed Modulation of Theta Frequency Consistent with Behavioral Effects on Encoding
Ehren L. Newman, Shea N. Gillet, Jason R. Climer, Michael E. Hasselmo
Journal of Neuroscience 11 December 2013, 33 (50) 19635-19646; DOI: 10.1523/JNEUROSCI.2586-13.2013

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Cholinergic Blockade Reduces Theta-Gamma Phase Amplitude Coupling and Speed Modulation of Theta Frequency Consistent with Behavioral Effects on Encoding
Ehren L. Newman, Shea N. Gillet, Jason R. Climer, Michael E. Hasselmo
Journal of Neuroscience 11 December 2013, 33 (50) 19635-19646; DOI: 10.1523/JNEUROSCI.2586-13.2013
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Keywords

  • theta
  • gamma
  • acetylcholine
  • entorhinal cortex
  • encoding
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