Article Figures & Data
Figures
- Figure 1.
Reconstructed schematic illustrating the localization of microdialysis probes (n = 22) in the cerebral cortex. Dotted outlines demark main cortical areas: motor cortex (MC), auditory cortex (AC), somatosensory cortex (SSC), and visual cortex (VC) and were taken from Supin et al. (2001) with the permission of Kluwer Academic. Microdialysis probes were grouped within four broad regions: frontal (F), parietal (P), central (C), and occipital (O). Each color represents an individual fur seal.
- Figure 2.
Typical chromatograms displaying the level of serotonin (5-HT) in dialysates collected from the central cortical region (probe 2L in Fig. 2) during bilaterally symmetrical EEG states—active waking (AW), quiet waking (QW), bilateral slow-wave sleep (BSWS), and rapid eye movement sleep (REM). Serotonin eluted at a retention time of ∼3.5 min.
- Figure 3.
A, EEG power in the δ frequency range (1.2–4 Hz; SWA) across the sleep–wake cycle—active waking (AW), quiet waking (QW), bilateral slow wave sleep (BSWS), left asymmetrical slow wave sleep (LASWS), right asymmetrical slow wave sleep (RASWS), and rapid eye movement (REM) sleep. Each column represents the mean + SEM of the percent change in SWA relative to quiet waking. B, Cortical 5-HT release across the sleep–wake cycle. Each column represent the mean + SEM of the percent change in 5-HT levels relative to QW for 9 and 13 probes in the left and right hemispheres, respectively.
- Figure 4.
Cortical serotonin (5-HT) release during various waking states—hosing down with water (AW-hose), feeding (AW-feed), active waking (AW), and quiet waking (QW). Each column represents the mean + SEM of the percent change in serotonin levels relative to QW for 9 and 13 probes in the left and right hemispheres, respectively.
- Figure 5.
Cortical serotonin (5-HT) and acetylcholine (ACh) release during slow-wave sleep (SWS)—bilateral SWS (BSWS), left asymmetrical SWS (LASWS), and right asymmetrical SWS (RASWS). 5-HT release was symmetrical during ASWS, whereas ACh release was highly lateralized. Each point represents the mean ± SEM of the percent change in neurotransmitter level relative to BSWS. 5-HT data shown here were obtained from 6 and 8 probes in the left and right hemisphere, respectively. ACh data shown were taken from our prior study (Lapierre et al. 2007) and were obtained from 4 probes in both the left and right hemisphere.
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