PrPC Controls via Protein Kinase A the Direction of Synaptic Plasticity in the Immature Hippocampus

Maddalena D. Caiati; Victoria F. Safiulina; Giorgia Fattorini; Sudhir Sivakumaran; Giuseppe Legname; Enrico Cherubini

doi:10.1523/JNEUROSCI.4149-12.2013

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Re:Response to Caiati and coauthors' article
Enrico Cherubini

Submitted on: 14 May 2013
Response to Caiati and coauthors' article
Marko Premzl , PhD

Submitted on: 10 May 2013

Submitted on: (14 May 2013)

Re:Response to Caiati and coauthors' article
Enrico Cherubini
Dr. Premzl has questioned the lack of citation of his work in our paper (Caiati et al., 2013). We are very familiar with his work and his contribution in the field of bioinformatics of prion proteins. Indeed, one of us has recently published a work (Poggiolini and Legname, 2012) where his contribution was rightly acknowledged. We believe however, that in the context of the present work his references are not relevant. We h...
Show More

Dr. Premzl has questioned the lack of citation of his work in our paper (Caiati et al., 2013). We are very familiar with his work and his contribution in the field of bioinformatics of prion proteins. Indeed, one of us has recently published a work (Poggiolini and Legname, 2012) where his contribution was rightly acknowledged. We believe however, that in the context of the present work his references are not relevant. We have indeed focused on the role of the PrPC protein in regulating the expression of postsynaptic cyclic AMP dependent protein kinase A at immature mossy fiber-CA3 synapses. This signaling molecule accounts for LTP in young but not in adult animals. We did not identify the signaling cascades downstream of PKA activation. MAPK (shown to be upregulated by PrPC in Premzl et al., 2005) is not required to trigger LTP in neonatal hippocampus (Yasuda et al., 2003). We felt that many papers were left out in the bibliography of our work and that we struggled to include only the most relevant and pertinent ones.
Citations
Caiati MD, Safiulina VF, Fattorini G, Sivakumaran S, Legname G, Cherubini E (2013) PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. J Neurosci 33:2973-2983.
Poggiolini I, Legname G (2012) Mapping the prion protein distribution in marsupials: insights from comparing opossum with mouse CNS. PLoS One 7(11):e50370. doi: 10.1371/journal.pone.0050370. Epub 2012 Nov 29
Premzl M, Delbridge M, Gready JE, Wilson P, Johnson M, Davis J, Kuczek E, Marshall Graves JA (2005) The prion protein gene: identifying regulatory signals using marsupial sequence. Gene 349:121-134.
Yasuda H, Barth AL, Stellwagen D, Malenka RC (2003) A developmental switch in the signaling cascades for LTP induction. Nat Neurosci 6:15-16.
Conflict of Interest:
I have no competing interests
Show Less

Competing Interests: None declared.
Submitted on: (10 May 2013)

Response to Caiati and coauthors' article
Marko Premzl , PhD, Scientist
The function of prion protein PrP has been elusive. One major contribution to this problem is the hypothesis that relates PrP and synaptic plasticity. The hypothesis was first proposed by Premzl and colleagues (Premzl et al., 2005). The hypothesis was additionally strengthened by arguments of Premzl and Gamulin (Premzl and Gamulin, 2007). These research articles have been cited cumulatively >50 times at present. It i...
Show More

The function of prion protein PrP has been elusive. One major contribution to this problem is the hypothesis that relates PrP and synaptic plasticity. The hypothesis was first proposed by Premzl and colleagues (Premzl et al., 2005). The hypothesis was additionally strengthened by arguments of Premzl and Gamulin (Premzl and Gamulin, 2007). These research articles have been cited cumulatively >50 times at present. It is therefore very surprising that Caiati et al. (2013) did not acknowledge or provide references for the sources of the hypothesis they tested (Caiati et al., 2013).
References
Premzl M, Delbridge M, Gready JE, Wilson P, Johnson M, Kuczek E, Graves JAM (2005) The prion protein gene: identifying regulatory signals using marsupial sequence. Gene 349:121-134.
Premzl M, Gamulin V (2007) Comparative genomic analysis of prion genes. BMC Genomics 8:1.
Caiati MD, Safiulina VF, Fattorini G, Sivakumaran S, Legname G, Cherubini E (2013) PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. 33:2973-2983.
Conflict of Interest:
None declared
Show Less

Competing Interests: None declared.

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Re:Response to Caiati and coauthors' article
Enrico Cherubini

Published on: 14 May 2013
Response to Caiati and coauthors' article
Marko Premzl , PhD

Published on: 10 May 2013

Published on: (14 May 2013)

Re:Response to Caiati and coauthors' article
Enrico Cherubini
Dr. Premzl has questioned the lack of citation of his work in our paper (Caiati et al., 2013). We are very familiar with his work and his contribution in the field of bioinformatics of prion proteins. Indeed, one of us has recently published a work (Poggiolini and Legname, 2012) where his contribution was rightly acknowledged. We believe however, that in the context of the present work his references are not relevant. We h...
Show More

Dr. Premzl has questioned the lack of citation of his work in our paper (Caiati et al., 2013). We are very familiar with his work and his contribution in the field of bioinformatics of prion proteins. Indeed, one of us has recently published a work (Poggiolini and Legname, 2012) where his contribution was rightly acknowledged. We believe however, that in the context of the present work his references are not relevant. We have indeed focused on the role of the PrPC protein in regulating the expression of postsynaptic cyclic AMP dependent protein kinase A at immature mossy fiber-CA3 synapses. This signaling molecule accounts for LTP in young but not in adult animals. We did not identify the signaling cascades downstream of PKA activation. MAPK (shown to be upregulated by PrPC in Premzl et al., 2005) is not required to trigger LTP in neonatal hippocampus (Yasuda et al., 2003). We felt that many papers were left out in the bibliography of our work and that we struggled to include only the most relevant and pertinent ones.
Citations
Caiati MD, Safiulina VF, Fattorini G, Sivakumaran S, Legname G, Cherubini E (2013) PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. J Neurosci 33:2973-2983.
Poggiolini I, Legname G (2012) Mapping the prion protein distribution in marsupials: insights from comparing opossum with mouse CNS. PLoS One 7(11):e50370. doi: 10.1371/journal.pone.0050370. Epub 2012 Nov 29
Premzl M, Delbridge M, Gready JE, Wilson P, Johnson M, Davis J, Kuczek E, Marshall Graves JA (2005) The prion protein gene: identifying regulatory signals using marsupial sequence. Gene 349:121-134.
Yasuda H, Barth AL, Stellwagen D, Malenka RC (2003) A developmental switch in the signaling cascades for LTP induction. Nat Neurosci 6:15-16.
Conflict of Interest:
I have no competing interests
Show Less

Competing Interests: None declared.
Published on: (10 May 2013)

Response to Caiati and coauthors' article
Marko Premzl , PhD, Scientist
The function of prion protein PrP has been elusive. One major contribution to this problem is the hypothesis that relates PrP and synaptic plasticity. The hypothesis was first proposed by Premzl and colleagues (Premzl et al., 2005). The hypothesis was additionally strengthened by arguments of Premzl and Gamulin (Premzl and Gamulin, 2007). These research articles have been cited cumulatively >50 times at present. It i...
Show More

The function of prion protein PrP has been elusive. One major contribution to this problem is the hypothesis that relates PrP and synaptic plasticity. The hypothesis was first proposed by Premzl and colleagues (Premzl et al., 2005). The hypothesis was additionally strengthened by arguments of Premzl and Gamulin (Premzl and Gamulin, 2007). These research articles have been cited cumulatively >50 times at present. It is therefore very surprising that Caiati et al. (2013) did not acknowledge or provide references for the sources of the hypothesis they tested (Caiati et al., 2013).
References
Premzl M, Delbridge M, Gready JE, Wilson P, Johnson M, Kuczek E, Graves JAM (2005) The prion protein gene: identifying regulatory signals using marsupial sequence. Gene 349:121-134.
Premzl M, Gamulin V (2007) Comparative genomic analysis of prion genes. BMC Genomics 8:1.
Caiati MD, Safiulina VF, Fattorini G, Sivakumaran S, Legname G, Cherubini E (2013) PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. 33:2973-2983.
Conflict of Interest:
None declared
Show Less

Competing Interests: None declared.

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PrP^C Controls via Protein Kinase A the Direction of Synaptic Plasticity in the Immature Hippocampus