Cover legend: As a rat is about to sample a tactile discriminanda in complete darkness solely using its whiskers, multiple anticipatory modulations occur in the somatosensory cortex and thalamus. These modulations (represented in red in the color-coded activity map) originate in M1 and are good predictors of speed and tactile performance. These simultaneous top-down modulations observed in multiple trigeminal pathways indicate that the trigeminal system does not operate based on a labeled line scheme. Cover design by Katie Zhuang, Nicolelis Labs. For more information, see the article by Pais-Vieira et al. (pages 4076–4093).