Article Information
- Received September 27, 2013
- Revision received January 16, 2014
- Accepted January 27, 2014
- First published March 5, 2014.
- Version of record published March 5, 2014.
Author Information
- Estefanía Moreno1,2,3,
- David Moreno-Delgado1,2,3,
- Gemma Navarro1,2,3,
- Hanne M. Hoffmann4,
- Silvia Fuentes4,
- Santi Rosell-Vilar4,
- Paola Gasperini1,2,3,
- Mar Rodríguez-Ruiz1,2,3,
- Mireia Medrano1,2,3,
- Josefa Mallol1,2,3,
- Antoni Cortés1,2,3,
- Vicent Casadó1,2,3,
- Carme Lluís1,2,3,
- Sergi Ferré5,
- Jordi Ortiz4,
- Enric Canela1,2,3,*, and
- Peter J. McCormick1,2,3,6,*
- 1Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED),
- 2Institute of Biomedicine of the University of Barcelona (IBUB) and
- 3Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, 08028 Spain,
- 4Neuroscience Institute and Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitat Autónoma de Barcelona, 08193 Bellaterra, Spain,
- 5National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, and
- 6School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom NR4 7TJ
Author contributions
Author contributions: E.M., D.M.-D., S. Fuentes, P.G., V.C., C.L., S. Ferré, J.O., P.J.M., and E.C. analyzed data; E.M., D.M.-D., C.L., S. Ferré, J.O., and P.J.M. wrote the paper; S. Fuentes, J.M., S. Ferré, and E.C. contributed unpublished reagents/analytic tools. E.M., D.M.-D., P.G., V.C., C.L., J.O., P.J.M., and E.C. designed research; E.M., D.M.-D., G.N., H.M.H., S. Fuentes, S.R.-V., P.G., M.R.-R., M.M., A.C., and V.C. performed research.
↵*E.C. and P.J.M. contributed equally to this work.
Disclosures
- Received September 27, 2013.
- Revision received January 16, 2014.
- Accepted January 27, 2014.
This study was supported by grants from the Spanish Ministerio de Ciencia y Tecnología (SAF2010-18472, SAF2011-23813, SAF2006-08240, SAF2009-12510, and Red de Trastornos Adictivos RD06/0001/0015) and by Intramural Funds of the National Institute on Drug Abuse to S. Ferré. P.J.M. is a Ramón y Cajal Fellow. We thank Jasmina Jiménez for technical help (University of Barcelona). We thank Laboratorios Esteve (Barcelona, Spain) for providing σ1 receptor KO and WT mice brains.
The authors declare no competing financial interests.
- Correspondence should be addressed to Peter J. McCormick, School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, UK NR4 7TJ. p.mccormick{at}uea.ac.uk
