Article Figures & Data
Figures
- Figure 1.
BOLD activity and time courses in rTPJ and rdlPFC. A, Clusters in rTPJ (peak: x = 60, y = −32, z = 24) and rdlPFC (peak: x = 42, y = 30, z = 26) from the whole-brain contrast thresholded at p < 0.0001 for viewing. B, D, Percentage signal change from rTPJ and rdlPFC from whole-brain (FDR: q < 0.05) is plotted for 8 s after stimulus onset, evaluated as good (blue) and bad (red) actions. Arrows indicate the first bin with significant increase. The rTPJ showed signal change earlier (4 s, T = 0.325, p = 0.002) and was significantly more responsive to bad actions, whereas the response in rdlPFC was later (6 s, T = 2.082, p = 0.022) and was greater for good actions. Bounds are SEM. C, BOLD activity in rdlPFC ROI (x = 40, y = 37, z = 26) for good actions significantly predicted praise ratings.
- Figure 2.
Justice sensitivity and postscan ratings predict moral sensitivity in ROIs dmPFC (top; x = 0, y = 54, z = 36) and rTPJ (bottom; x = 62, y = −54, z = 16). Other-oriented justice sensitivity was positively correlated with activity in dmPFC (A) and rTPJ (C) for Bad > Good. B, Greater activity for Bad > Good in dmPFC was related to higher praise ratings (green). D, Greater activity in rTPJ correlated with increased praise (green) and blame (red) ratings.
- Figure 3.
A, Regions with greater activity for judgments made during Motive blocks (p < 0.001). B, Whole-brain responses for good actions versus bad actions (FDR: q < 0.05). Striatum is circled. C, Increased functional connectivity seeded in rTPJ (x = 62, y = −54, z = 16; circled in D) is shown on a midline sagittal slice. D, Increased coupling with ACC/mPFC (x = 0, y = 46, z = 10) and a cluster in rdlPFC (peak: x = 54, y = 20, z = 16) that overlaps with that found in the whole-brain Good > Bad contrast.
Tables
- Table 1.
Brain regions showing significant hemodynamic increase to moral valence of actions performed by othersa
Contrast Brain region MNI coordinates Cluster size T x y z Bad > good R supramarginal gyrus 58 −32 24 1390 7.54 L insula −52 6 4 122 4.15 L supramarginal gyrus −54 −32 22 1233 8.67 L midcingulate −12 −28 42 145 4.87 R midcingulate 14 −28 40 10 3.37 L superior parietal lobule −22 −56 68 66 4.41 R superior frontal gyrus 14 −4 74 45 4.15 L hippocampus −20 −12 −10 7 3.46 R hippocampus 38 −10 −18 5 3.38 Good > bad R middle temporal 58 −2 −24 47 3.92 L middle temporal −56 −2 −24 146 5.38 L inferior temporal −56 −44 −18 380 5.40 R inferior temporal 56 −54 −16 83 3.83 L inferior frontal −46 40 −10 605 7.02 R inferior frontal 34 32 −14 81 3.82 R dlPFC 46 48 12 799 4.68 L dlPFC −40 10 48 1257 7.00 L precuneus −2 −60 30 230 4.30 L insula −34 −20 18 141 4.51 R insula 36 −6 22 30 3.69 L caudate −18 −2 24 35 3.49 R caudate 18 2 22 29 3.70 L superior medial frontal −4 28 40 1102 5.22 R superior frontal 24 22 58 152 3.75 ↵aVoxel-wise FDR: q < 0.001. R, Right; L, left.
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