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Articles, Cellular/Molecular

Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination

Stacey E. Wahl, Lauren E. McLane, Kathryn K. Bercury, Wendy B. Macklin and Teresa L. Wood
Journal of Neuroscience 26 March 2014, 34 (13) 4453-4465; https://doi.org/10.1523/JNEUROSCI.4311-13.2014
Stacey E. Wahl
1Department of Neurology and Neuroscience, New Jersey Medical School Cancer Center, Rutgers Biomedical and Health Sciences, Newark, New Jersey 07103, and
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Lauren E. McLane
1Department of Neurology and Neuroscience, New Jersey Medical School Cancer Center, Rutgers Biomedical and Health Sciences, Newark, New Jersey 07103, and
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Kathryn K. Bercury
2Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045
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Wendy B. Macklin
2Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045
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Teresa L. Wood
1Department of Neurology and Neuroscience, New Jersey Medical School Cancer Center, Rutgers Biomedical and Health Sciences, Newark, New Jersey 07103, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4311-13.2014
PubMed 
24671992
Published By 
Society for Neuroscience
History 
  • Received October 7, 2013
  • Revision received February 3, 2014
  • Accepted February 8, 2014
  • First published March 26, 2014.
  • Version of record published March 26, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/344453-13$15.00/0

Author Information

  1. Stacey E. Wahl1,
  2. Lauren E. McLane1,
  3. Kathryn K. Bercury2,
  4. Wendy B. Macklin2, and
  5. Teresa L. Wood1
  1. 1Department of Neurology and Neuroscience, New Jersey Medical School Cancer Center, Rutgers Biomedical and Health Sciences, Newark, New Jersey 07103, and
  2. 2Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045
View Full Text

Author contributions

  1. Author contributions: S.E.W. designed research; S.E.W., L.E.M., and K.K.B. performed research; S.E.W., L.E.M., W.B.M., and T.L.W. analyzed data; S.E.W., L.E.M., and T.L.W. wrote the paper.

Disclosures

    • Received October 7, 2013.
    • Revision received February 3, 2014.
    • Accepted February 8, 2014.
  • This work was supported by National Multiple Sclerosis Society Grant RG4015 to T.L.W., National Institute of Neurological Disorders & Stroke Grant NS082203 to W.B.M. and T.L.W., and National Research Service Award NS076187 to S.E.W. We thank Dr. Christopher Lynch, Penn State College of Medicine for providing the mTORtm1.1Clyn floxed mice; Dr. Klaus Nave for permission to use the CNP-Cre mouse line; Dr. Holly Colognato for providing the CNP-Cre mice; Corey Goyeneche for technical assistance; Dorothy Dill and Hilary Sachs for assistance with EM; and Jared Ahrendsen for helpful discussions.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Teresa L. Wood, Department of Neurology & Neuroscience and Cancer Center H1200, New Jersey Medical School/Rutgers Biomedical & Health Sciences, 205 S. Orange Avenue, Newark, NJ 07101-1709. woodte{at}njms.rutgers.edu

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The Journal of Neuroscience: 34 (13)
Journal of Neuroscience
Vol. 34, Issue 13
26 Mar 2014
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Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination
Stacey E. Wahl, Lauren E. McLane, Kathryn K. Bercury, Wendy B. Macklin, Teresa L. Wood
Journal of Neuroscience 26 March 2014, 34 (13) 4453-4465; DOI: 10.1523/JNEUROSCI.4311-13.2014

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Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination
Stacey E. Wahl, Lauren E. McLane, Kathryn K. Bercury, Wendy B. Macklin, Teresa L. Wood
Journal of Neuroscience 26 March 2014, 34 (13) 4453-4465; DOI: 10.1523/JNEUROSCI.4311-13.2014
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Keywords

  • differentiation
  • mTOR
  • myelination
  • oligodendrocyte
  • signaling

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