Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
Articles, Cellular/Molecular

Mutation of Putative GRK Phosphorylation Sites in the Cannabinoid Receptor 1 (CB1R) Confers Resistance to Cannabinoid Tolerance and Hypersensitivity to Cannabinoids in Mice

Daniel J. Morgan, Brian J. Davis, Chris S. Kearn, David Marcus, Alex J. Cook, Jim Wager-Miller, Alex Straiker, Michael H. Myoga, Jeffrey Karduck, Emma Leishman, Laura J. Sim-Selley, Traci A. Czyzyk, Heather B. Bradshaw, Dana E. Selley and Ken Mackie
Journal of Neuroscience 9 April 2014, 34 (15) 5152-5163; https://doi.org/10.1523/JNEUROSCI.3445-12.2014
Daniel J. Morgan
1Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405,
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brian J. Davis
1Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405,
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chris S. Kearn
3Department of Anesthesiology, University of Washington School of Medicine, Seattle, Washington 98195,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Marcus
1Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405,
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alex J. Cook
1Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405,
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jim Wager-Miller
1Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405,
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alex Straiker
1Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405,
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael H. Myoga
3Department of Anesthesiology, University of Washington School of Medicine, Seattle, Washington 98195,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeffrey Karduck
1Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405,
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emma Leishman
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura J. Sim-Selley
4Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Traci A. Czyzyk
1Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405,
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
5Department of Physiology, Mayo Clinic Arizona, Scottsdale, Arizona 85259
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Heather B. Bradshaw
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dana E. Selley
4Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ken Mackie
1Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405,
2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3445-12.2014
PubMed 
24719095
Published By 
Society for Neuroscience
History 
  • Received July 16, 2012
  • Revision received January 28, 2014
  • Accepted February 19, 2014
  • First published April 9, 2014.
  • Version of record published April 9, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/345152-12$15.00/0

Author Information

  1. Daniel J. Morgan1,2,
  2. Brian J. Davis1,2,
  3. Chris S. Kearn3,†,
  4. David Marcus1,2,
  5. Alex J. Cook1,2,
  6. Jim Wager-Miller1,2,
  7. Alex Straiker1,2,
  8. Michael H. Myoga3,
  9. Jeffrey Karduck1,2,
  10. Emma Leishman2,
  11. Laura J. Sim-Selley4,
  12. Traci A. Czyzyk1,2,5,
  13. Heather B. Bradshaw2,
  14. Dana E. Selley4, and
  15. Ken Mackie1,2
  1. 1Gill Center for Biomolecular Science, Indiana University, Bloomington, Indiana 47405,
  2. 2Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405,
  3. 3Department of Anesthesiology, University of Washington School of Medicine, Seattle, Washington 98195,
  4. 4Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298, and
  5. 5Department of Physiology, Mayo Clinic Arizona, Scottsdale, Arizona 85259
  • ↵†Deceased, February 19, 2009.

View Full Text

Author contributions

  1. Author contributions: D.J.M., A.S., L.J.S.-S., T.A.C., H.B.B., D.E.S., and K.M. designed research; D.J.M., B.J.D., C.S.K., D.M., A.J.C., J.W.-M., A.S., M.H.M., J.K., and E.L. performed research; C.S.K. and M.H.M. contributed unpublished reagents/analytic tools; D.J.M., D.M., J.W.-M., A.S., L.J.S.-S., H.B.B., D.E.S., and K.M. analyzed data; D.J.M., A.S., L.J.S.-S., T.A.C., H.B.B., D.E.S., and K.M. wrote the paper.

  • ↵†Deceased, February 19, 2009.

Disclosures

    • Received July 16, 2012.
    • Revision received January 28, 2014.
    • Accepted February 19, 2014.
  • This work has been supported by National Institutes of Health Grants DA011322, DA021696, DA014277, DA036385, and DA015916. Additional support was provided by the Indiana Academy of Sciences, the Indiana University METACyt Initiative (funded in part by a grant from the Lilly Foundation), and the Linda and Jack Gill Center for Biomolecular Science. We thank G. Stanley McKnight and Richard Palmiter for many helpful discussions; and Thong Su, Courtney Hatheway, Natalie Barker, Alex Hughes, Jordan Cox, Aaron Tomarchio, and Jill Farnsworth for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Daniel J. Morgan, 500 University Drive, Hershey, PA 17033, dmorgan1{at}hmc.psu.edu; or Ken Mackie, 1101 East 10th Street, Bloomington, IN 47405, kmackie{at}indiana.edu

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-12-10
to
E.g., 2025-12-10

Article usage: January 2018 to December 2025

AbstractFullPdf
Jan 201812219
Feb 20187174
Mar 20188245
Apr 20188378
May 201810210
Jun 20183263
Jul 20184156
Aug 2018142712
Sep 20187403
Oct 201815235
Nov 20187275
Dec 20185123
Total 201810029063
Jan 20199209
Feb 2019202012
Mar 2019241611
Apr 2019181412
May 20198174
Jun 201918116
Jul 201981311
Aug 20191615415
Oct 201919737
Nov 2019121611
Dec 20197143
Total 2019159368101
Jan 20206102
Feb 202012148
Mar 202012155
May 2020112911
Jun 20203145
Jul 202081110
Aug 20205144
Sep 2020142714
Oct 2020133511
Nov 2020153712
Dec 202015335
Total 202011423987
Jan 202183516
Feb 202192610
Mar 2021123112
Apr 202110229
May 20219226
Jun 2021103513
Jul 202182511
Aug 202133323
Sep 2021152611
Oct 2021143021
Nov 202172420
Dec 202162111
Total 2021111330163
Jan 2022112810
Feb 202214224
Mar 202272221
Apr 2022153114
May 202282314
Jun 202273121
Jul 202216275
Aug 20226286
Sep 202218178
Oct 202292212
Nov 2022595
Dec 20225144
Total 2022121274124
Jan 20232299
Feb 20234202
Mar 202393717
Apr 2023101811
May 2023142012
Jun 202313183
Jul 202341815
Aug 20233166
Sep 20236189
Oct 2023123210
Nov 202317249
Dec 202322249
Total 2023116274112
Jan 2024112337
Feb 2024242517
Mar 202462118
Apr 2024913212
May 20246358
Jun 202421812
Jul 20244239
Aug 202422411
Sep 202422719
Oct 202492913
Nov 20247248
Dec 20245306
Total 202487411170
Jan 2025121910
Feb 2025114814
Mar 202583914
Apr 20255257
May 202562110
Jun 202542613
Jul 20255147
Aug 202552613
Sep 2025163716
Oct 2025124011
Nov 20251510716
Dec 2025377
Total 2025102409138
Total9102595958
Back to top

In this issue

The Journal of Neuroscience: 34 (15)
Journal of Neuroscience
Vol. 34, Issue 15
9 Apr 2014
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Advertising (PDF)
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Mutation of Putative GRK Phosphorylation Sites in the Cannabinoid Receptor 1 (CB1R) Confers Resistance to Cannabinoid Tolerance and Hypersensitivity to Cannabinoids in Mice
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Mutation of Putative GRK Phosphorylation Sites in the Cannabinoid Receptor 1 (CB1R) Confers Resistance to Cannabinoid Tolerance and Hypersensitivity to Cannabinoids in Mice
Daniel J. Morgan, Brian J. Davis, Chris S. Kearn, David Marcus, Alex J. Cook, Jim Wager-Miller, Alex Straiker, Michael H. Myoga, Jeffrey Karduck, Emma Leishman, Laura J. Sim-Selley, Traci A. Czyzyk, Heather B. Bradshaw, Dana E. Selley, Ken Mackie
Journal of Neuroscience 9 April 2014, 34 (15) 5152-5163; DOI: 10.1523/JNEUROSCI.3445-12.2014

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Mutation of Putative GRK Phosphorylation Sites in the Cannabinoid Receptor 1 (CB1R) Confers Resistance to Cannabinoid Tolerance and Hypersensitivity to Cannabinoids in Mice
Daniel J. Morgan, Brian J. Davis, Chris S. Kearn, David Marcus, Alex J. Cook, Jim Wager-Miller, Alex Straiker, Michael H. Myoga, Jeffrey Karduck, Emma Leishman, Laura J. Sim-Selley, Traci A. Czyzyk, Heather B. Bradshaw, Dana E. Selley, Ken Mackie
Journal of Neuroscience 9 April 2014, 34 (15) 5152-5163; DOI: 10.1523/JNEUROSCI.3445-12.2014
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • cannabinoid
  • CB1
  • desensitization
  • GPCR
  • THC
  • tolerance

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Articles

  • Memory Retrieval Has a Dynamic Influence on the Maintenance Mechanisms That Are Sensitive to ζ-Inhibitory Peptide (ZIP)
  • Neurophysiological Evidence for a Cortical Contribution to the Wakefulness-Related Drive to Breathe Explaining Hypocapnia-Resistant Ventilation in Humans
  • Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
Show more Articles

Cellular/Molecular

  • Widely Used CaMKII Regulatory Segment Mutations Cause Tight Actinin Binding and Dendritic Spine Enlargement in Unstimulated Neurons
  • High-Pressure Freezing EM Tomography of Entire Ribbon Synapses in the Retina
  • Identifying Key Regulators in Odorant Receptor Trafficking
Show more Cellular/Molecular
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.