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PreviousNext
Featured ArticleArticles, Development/Plasticity/Repair

EphA4-Mediated Ipsilateral Corticospinal Tract Misprojections Are Necessary for Bilateral Voluntary Movements But Not Bilateral Stereotypic Locomotion

Najet Serradj, Sónia Paixão, Tomasz Sobocki, Mitchell Feinberg, Rüdiger Klein, Klas Kullander and John H. Martin
Journal of Neuroscience 9 April 2014, 34 (15) 5211-5221; DOI: https://doi.org/10.1523/JNEUROSCI.4848-13.2014
Najet Serradj
1Department of Physiology, Pharmacology and Neuroscience, City College of the City University of New York, New York, New York 10031;
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Sónia Paixão
2Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany,
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Tomasz Sobocki
1Department of Physiology, Pharmacology and Neuroscience, City College of the City University of New York, New York, New York 10031;
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Mitchell Feinberg
1Department of Physiology, Pharmacology and Neuroscience, City College of the City University of New York, New York, New York 10031;
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Rüdiger Klein
2Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany,
3Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany; and
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Klas Kullander
4Department of Neuroscience, Science for Life Laboratory, University of Uppsala, 75124 Uppsala, Sweden
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John H. Martin
1Department of Physiology, Pharmacology and Neuroscience, City College of the City University of New York, New York, New York 10031;
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4848-13.2014
PubMed 
24719100
Published By 
Society for Neuroscience
History 
  • Received November 18, 2013
  • Revision received March 2, 2014
  • Accepted March 6, 2014
  • First published April 9, 2014.
  • Version of record published April 9, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/345211-11$15.00/0

Author Information

  1. Najet Serradj1,
  2. Sónia Paixão2,
  3. Tomasz Sobocki1,
  4. Mitchell Feinberg1,
  5. Rüdiger Klein2,3,
  6. Klas Kullander4, and
  7. John H. Martin1
  1. 1Department of Physiology, Pharmacology and Neuroscience, City College of the City University of New York, New York, New York 10031;
  2. 2Department of Molecules–Signaling–Development, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany,
  3. 3Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany; and
  4. 4Department of Neuroscience, Science for Life Laboratory, University of Uppsala, 75124 Uppsala, Sweden
View Full Text

Author contributions

  1. Author contributions: N.S., S.P., R.K., K.K., and J.H.M. designed research; N.S., S.P., T.S., and M.F. performed research; N.S., S.P., T.S., M.F., and J.H.M. analyzed data; N.S. and J.H.M. wrote the paper.

Disclosures

    • Received November 18, 2013.
    • Revision received March 2, 2014.
    • Accepted March 6, 2014.
  • This work was supported by National Institutes of Health (Grants R01NS036835 and R01NS079569 to J.H.M.), the Max-Planck Society and the Deutsche Forschungsgemeinschaft (Grant SFB870 to R.K.), and the Swedish Medical Research Council, Hållsten, Ländells, and Swedish Brain Foundations (to K.K.). K.K. is a Royal Swedish Academy of Sciences Research Fellow supported by a grant from the Knut and Alice Wallenberg Foundation. We thank Xiuli Wu for histochemistry and histology, Aarathi Balijepalli for help with behavioral analysis, Lice Ghilardi and Kathleen Friel for statistical consulting, and Trevor Drew for comments on the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to John H. Martin, PhD, Department of Physiology, Pharmacology, and Neuroscience, City College of the City University of New York, 160 Convent Avenue, New York, NY 10031. jmartin{at}ccny.cuny.edu

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The Journal of Neuroscience: 34 (15)
Journal of Neuroscience
Vol. 34, Issue 15
9 Apr 2014
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EphA4-Mediated Ipsilateral Corticospinal Tract Misprojections Are Necessary for Bilateral Voluntary Movements But Not Bilateral Stereotypic Locomotion
Najet Serradj, Sónia Paixão, Tomasz Sobocki, Mitchell Feinberg, Rüdiger Klein, Klas Kullander, John H. Martin
Journal of Neuroscience 9 April 2014, 34 (15) 5211-5221; DOI: 10.1523/JNEUROSCI.4848-13.2014

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EphA4-Mediated Ipsilateral Corticospinal Tract Misprojections Are Necessary for Bilateral Voluntary Movements But Not Bilateral Stereotypic Locomotion
Najet Serradj, Sónia Paixão, Tomasz Sobocki, Mitchell Feinberg, Rüdiger Klein, Klas Kullander, John H. Martin
Journal of Neuroscience 9 April 2014, 34 (15) 5211-5221; DOI: 10.1523/JNEUROSCI.4848-13.2014
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Keywords

  • Corticospinal tract
  • EphA4
  • locomotion
  • motor cortex
  • reaching

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