Articles, Cellular/Molecular

Progressive Degeneration of Dopaminergic Neurons through TRP Channel-Induced Cell Death

Archana Nagarajan, Ye Ning, Kaja Reisner, Zafir Buraei, Jan Petter Larsen, Oliver Hobert and Maria Doitsidou
Journal of Neuroscience 23 April 2014, 34 (17) 5738-5746; https://doi.org/10.1523/JNEUROSCI.4540-13.2014

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4540-13.2014
PubMed 
24760834
Published By 
Society for Neuroscience
History 
  • Received October 25, 2013
  • Revision received February 13, 2014
  • Accepted March 7, 2014
  • First published April 23, 2014.
  • Version of record published April 23, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/345738-09$15.00/0

Author Information

  1. Archana Nagarajan1,
  2. Ye Ning2,
  3. Kaja Reisner1,
  4. Zafir Buraei3,
  5. Jan Petter Larsen2,
  6. Oliver Hobert4,*, and
  7. Maria Doitsidou1,2,4,*
  1. 1Center for Organelle Research, University of Stavanger, 4036 Stavanger, Norway,
  2. 2Norwegian Center for Movement Disorders, Stavanger University Hospital, 4011 Stavanger, Norway,
  3. 3Department of Biology and Health Sciences, Pace University, New York, New York 10038, and
  4. 4Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032
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Author contributions

  1. Author contributions: O.H. and M.D. designed research; A.N., Y.N., K.R., and M.D. performed research; J.P.L. and O.H. contributed unpublished reagents/analytic tools; A.N., Z.B., and M.D. analyzed data; A.N., O.H., and M.D. wrote the paper.

  2. ↵*O.H. and M.D. contributed equally to this work.

Disclosures

    • Received October 25, 2013.
    • Revision received February 13, 2014.
    • Accepted March 7, 2014.

  • This work was funded by MJFF Rapid Response Innovation Awards to M.D. and O.H., Marie Curie Fellowship to M.D. (IRG 276950), Fellesløftet-NFR (213957) to M.D., Helse Vest Fellowship (911724) to M.D., Helse Vest project Grant (911732) to M.D., Norwegian Parkinson's Associations Grant 2011 to M.D., the National Institutes of Health (R01NS050266 to O.H.), and the Howard Hughes Medical Institute. We thank CGC for strains; Alex Boyanov, Jason Han, and Surinder Narula for technical assistance; Shawn Xu lab for kindly providing the Pdat-1::trp-4 plasmid; Dr. Jodi Maple Grødem and Tatiana Popovitchenko for comments on this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Oliver Hobert, Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, or38{at}columbia.edu; or Maria Doitsidou, Center for Organelle Research, University of Stavanger, N-4036 Stavanger, Norway, maria.doitsidou{at}uis.no

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Progressive Degeneration of Dopaminergic Neurons through TRP Channel-Induced Cell Death
Archana Nagarajan, Ye Ning, Kaja Reisner, Zafir Buraei, Jan Petter Larsen, Oliver Hobert, Maria Doitsidou
Journal of Neuroscience 23 April 2014, 34 (17) 5738-5746; DOI: 10.1523/JNEUROSCI.4540-13.2014
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  • Published on: (26 September 2014)
    Page navigation anchor for An overactivation of mGluRs via TRP channels produces necrotic death in DAergic neurons
    An overactivation of mGluRs via TRP channels produces necrotic death in DAergic neurons

    The work of Nagarajan et al. (2014) on C. elegans mutants shows that subunits of a transient receptor potential (TRP) channel allow calcium to enter the cell, thus leading to necrotic-like death of dopaminergic neurons. We believe that the toxic action of beta-N -Methylamino alanine (BMAA) in dopaminergic neurons of rodents (Cucchiaroni et al., 2010) could recapitulate some features of cell death described in the worm....

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    Competing Interests: None declared.