Figure 7. Model of L5 ACC. A, Network architecture. B, C, Calibration of the model. B, F-I curve for pyramidal neurons. C, F-I curve for FS interneurons in sham (blue) and CCI (red) conditions. The average F-I curve from the data (large disks) is fitted with the model (solid line). ±SEM of the data (small disks) are also fitted with the model (shaded area). D, E, Response of the network (D, excitatory neurons; E, inhibitory neurons) to step current in the pool of excitatory neurons for the sham condition (blue) and for the CCI condition (red). F, G, Stationary network response (F, excitatory neurons; G, inhibitory neurons) to a given excitatory current for the sham condition (blue) and for the CCI condition (red). The dashed line indicates the effective transfer function for the mean parameters. The solid line indicates the median; the shaded area represents the interval between the first and third quartile when the parameters are sampled consistently with the uncertainty of the mean (see Materials and Methods). Inset, Distribution of responses at 300 pA.