Article Information
- Received December 18, 2013
- Revision received February 5, 2014
- Accepted March 17, 2014
- First published April 23, 2014.
- Version of record published April 23, 2014.
Author Information
- Arnaldo Parra-Damas1,2,*,
- Jorge Valero1,2,*,
- Meng Chen1,2,
- Judit España1,2,
- Elsa Martín1,2,
- Isidro Ferrer2,3,
- José Rodríguez-Alvarez1,2, and
- Carlos A. Saura1,2
- 1Institut de Neurociències, Department de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona 08193, Spain, and
- 2Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED) and
- 3Institut de Neuropatologia, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona 08907, Spain
Author contributions
Author contributions: A.P.-D., J.V., M.C., J.E., I.F., J.R.-A., and C.A.S. designed research; A.P.-D., J.V., M.C., J.E., E.M., and C.A.S. performed research; I.F. and J.R.-A. contributed unpublished reagents/analytic tools; A.P.-D., J.V., M.C., J.E., and E.M. analyzed data; C.A.S. wrote the paper.
↵*A.P.-D. and J.V. contributed equally to this work.
Disclosures
- Received December 18, 2013.
- Revision received February 5, 2014.
- Accepted March 17, 2014.
This work was supported by grants from the Ministerio de Economia y Competitividad (SAF2010-20925 and CIBERNED CB06/05/0042), and the European Commission (MEMOSAD project, FP7-200611). A.P.-D and M.C. are supported by doctoral fellowships from Ministerio de Ciencia e Innovación (BES-2011-044405) and China Scholarship Council, respectively. We thank L. Mucke for providing the APPSw,Ind mice and J.-R. Cardinaux for mouse Crtc1 plasmid, Mar Castillo and Núria Barba from the Institut de Neurociències Histology and Microscope Units for technical assistance, the Servei de Genòmica Bioinformàtica-IBB-UAB, the Unitat de Producció de Vectors Virals (UPVV)-UAB for generating the AAV vectors, and S. Ginés for critical comments of the paper, and the Fundación CIEN (Instituto de Salud Carlos III, Spain) for human brain samples.
The authors declare no competing financial interests.
- Correspondence should be addressed to Dr Carlos A. Saura, Institut de Neurociències, Facultat de Medicina M2-113, Universitat Autònoma de Barcelona, Bellaterra (Barcelona), Spain 08193. carlos.saura{at}uab.es
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