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Articles, Development/Plasticity/Repair

The Role of Arp2/3 in Growth Cone Actin Dynamics and Guidance Is Substrate Dependent

José E. San Miguel-Ruiz and Paul C. Letourneau
Journal of Neuroscience 23 April 2014, 34 (17) 5895-5908; DOI: https://doi.org/10.1523/JNEUROSCI.0672-14.2014
José E. San Miguel-Ruiz
1Departments of Neuroscience and
2Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455
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Paul C. Letourneau
1Departments of Neuroscience and
2Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455
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Abstract

During development extrinsic guidance cues modulate the peripheral actin network in growth cones to direct axons to their targets. We wanted to understand the role of the actin nucleator Arp2/3 in growth cone actin dynamics and guidance. Since growth cones migrate in association with diverse adhesive substrates during development, we probed the hypothesis that the functional significance of Arp2/3 is substrate dependent. We report that Arp2/3 inhibition led to a reduction in the number of filopodia and growth cone F-actin content on laminin and L1. However, we found substrate-dependent differences in growth cone motility, actin retrograde flow, and guidance after Arp2/3 inhibition, suggesting that its role, and perhaps that of other actin binding proteins, in growth cone motility is substrate dependent.

  • actin
  • Arp2/3
  • growth cone
  • guidance
  • L1 CAM
  • laminin
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The Journal of Neuroscience: 34 (17)
Journal of Neuroscience
Vol. 34, Issue 17
23 Apr 2014
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The Role of Arp2/3 in Growth Cone Actin Dynamics and Guidance Is Substrate Dependent
José E. San Miguel-Ruiz, Paul C. Letourneau
Journal of Neuroscience 23 April 2014, 34 (17) 5895-5908; DOI: 10.1523/JNEUROSCI.0672-14.2014

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The Role of Arp2/3 in Growth Cone Actin Dynamics and Guidance Is Substrate Dependent
José E. San Miguel-Ruiz, Paul C. Letourneau
Journal of Neuroscience 23 April 2014, 34 (17) 5895-5908; DOI: 10.1523/JNEUROSCI.0672-14.2014
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Keywords

  • actin
  • Arp2/3
  • growth cone
  • guidance
  • L1 CAM
  • laminin

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