LMTK3 Deficiency Causes Pronounced Locomotor Hyperactivity and Impairs Endocytic Trafficking

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¹Division of Oncology and
²Division of Neuronal Network, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan,
³Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan,
⁴Laboratory of Molecular Recognition, Graduate School of Arts and Sciences, Yokohama City University, Yokohama 236-0027, Japan, and
⁵Cell Signal Unit, Okinawa Institute of Science and Technology, Onna-son, Okinawa 904-0495, Japan

T. Inoue's present address: Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
T. Nakazawa's present address: iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

Author contributions: T.I., T.M., and Tadashi Yamamoto designed research; T.I., N.H., Y.K., S.K., T.A., and Toshifumi Yamamoto performed research; T.I., N.H., T.N., Y.K., S.K., Toshifumi Yamamoto, T.M., and Tadashi Yamamoto analyzed data; T.I. and Tadashi Yamamoto wrote the paper.

T. Inoue's present address: Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
T. Nakazawa's present address: iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

This work was supported by the Strategic Research Program for Brain Sciences and the Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. We thank M. Tomomura (Meikai University School of Dentistry) for mouse Lmtk3 cDNA and anti-mouse LMTK3 antibody and S. D. Aird for critical reading of the manuscript.
The authors declare no competing financial interests.
Correspondence should be addressed to either of the following: Dr. Toshiya Manabe, Division of Neuronal Network, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan, tmanabe-tky{at}umin.ac.jp; or Dr. Tadashi Yamamoto, Cell Signal Unit, Okinawa Institute of Science and Technology, Onna-son, Okinawa 904-0495, Japan, tyamamot{at}ims.u-tokyo.ac.jp

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