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Articles, Cellular/Molecular

LMTK3 Deficiency Causes Pronounced Locomotor Hyperactivity and Impairs Endocytic Trafficking

Takeshi Inoue, Naosuke Hoshina, Takanobu Nakazawa, Yuji Kiyama, Shizuka Kobayashi, Takaya Abe, Toshifumi Yamamoto, Toshiya Manabe and Tadashi Yamamoto
Journal of Neuroscience 23 April 2014, 34 (17) 5927-5937; https://doi.org/10.1523/JNEUROSCI.1621-13.2014
Takeshi Inoue
1Division of Oncology and
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Naosuke Hoshina
1Division of Oncology and
5Cell Signal Unit, Okinawa Institute of Science and Technology, Onna-son, Okinawa 904-0495, Japan
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Takanobu Nakazawa
1Division of Oncology and
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Yuji Kiyama
2Division of Neuronal Network, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan,
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Shizuka Kobayashi
2Division of Neuronal Network, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan,
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Takaya Abe
3Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan,
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Toshifumi Yamamoto
4Laboratory of Molecular Recognition, Graduate School of Arts and Sciences, Yokohama City University, Yokohama 236-0027, Japan, and
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Toshiya Manabe
2Division of Neuronal Network, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan,
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Tadashi Yamamoto
1Division of Oncology and
5Cell Signal Unit, Okinawa Institute of Science and Technology, Onna-son, Okinawa 904-0495, Japan
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1621-13.2014
PubMed 
24760852
Published By 
Society for Neuroscience
History 
  • Received April 17, 2013
  • Revision received March 2, 2014
  • Accepted March 19, 2014
  • First published April 23, 2014.
  • Version of record published April 23, 2014.
Copyright & Usage 
Copyright © 2014 the authors 0270-6474/14/345927-11$15.00/0

Author Information

  1. Takeshi Inoue1,
  2. Naosuke Hoshina1,5,
  3. Takanobu Nakazawa1,
  4. Yuji Kiyama2,
  5. Shizuka Kobayashi2,
  6. Takaya Abe3,
  7. Toshifumi Yamamoto4,
  8. Toshiya Manabe2, and
  9. Tadashi Yamamoto1,5
  1. 1Division of Oncology and
  2. 2Division of Neuronal Network, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan,
  3. 3Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan,
  4. 4Laboratory of Molecular Recognition, Graduate School of Arts and Sciences, Yokohama City University, Yokohama 236-0027, Japan, and
  5. 5Cell Signal Unit, Okinawa Institute of Science and Technology, Onna-son, Okinawa 904-0495, Japan
  • T. Inoue's present address: Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

  • T. Nakazawa's present address: iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

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Author contributions

  1. Author contributions: T.I., T.M., and Tadashi Yamamoto designed research; T.I., N.H., Y.K., S.K., T.A., and Toshifumi Yamamoto performed research; T.I., N.H., T.N., Y.K., S.K., Toshifumi Yamamoto, T.M., and Tadashi Yamamoto analyzed data; T.I. and Tadashi Yamamoto wrote the paper.

  • T. Inoue's present address: Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

  • T. Nakazawa's present address: iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

Disclosures

    • Received April 17, 2013.
    • Revision received March 2, 2014.
    • Accepted March 19, 2014.
  • This work was supported by the Strategic Research Program for Brain Sciences and the Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. We thank M. Tomomura (Meikai University School of Dentistry) for mouse Lmtk3 cDNA and anti-mouse LMTK3 antibody and S. D. Aird for critical reading of the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Dr. Toshiya Manabe, Division of Neuronal Network, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan, tmanabe-tky{at}umin.ac.jp; or Dr. Tadashi Yamamoto, Cell Signal Unit, Okinawa Institute of Science and Technology, Onna-son, Okinawa 904-0495, Japan, tyamamot{at}ims.u-tokyo.ac.jp

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Total 20253515570
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The Journal of Neuroscience: 34 (17)
Journal of Neuroscience
Vol. 34, Issue 17
23 Apr 2014
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LMTK3 Deficiency Causes Pronounced Locomotor Hyperactivity and Impairs Endocytic Trafficking
Takeshi Inoue, Naosuke Hoshina, Takanobu Nakazawa, Yuji Kiyama, Shizuka Kobayashi, Takaya Abe, Toshifumi Yamamoto, Toshiya Manabe, Tadashi Yamamoto
Journal of Neuroscience 23 April 2014, 34 (17) 5927-5937; DOI: 10.1523/JNEUROSCI.1621-13.2014

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LMTK3 Deficiency Causes Pronounced Locomotor Hyperactivity and Impairs Endocytic Trafficking
Takeshi Inoue, Naosuke Hoshina, Takanobu Nakazawa, Yuji Kiyama, Shizuka Kobayashi, Takaya Abe, Toshifumi Yamamoto, Toshiya Manabe, Tadashi Yamamoto
Journal of Neuroscience 23 April 2014, 34 (17) 5927-5937; DOI: 10.1523/JNEUROSCI.1621-13.2014
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Keywords

  • endocytosis
  • hyperactivity
  • LMTK
  • locomotor
  • membrane trafficking

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